#CryoEM shows the human #HECT domain-containing E3 #ligase #UBR5 forms an 𝛂-solenoid scaffold from an antiparallel dimer, and efficiently extends #ubiquitin chains on primed substrates such as #AKIRIN2
@haselbachlab @IMPvienna Nick Brown #UNC_PHCO
#RefereedPreprint ℅ @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2022113348
#HECT
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