“Beyond its oral pathogenicity, F. nucleatum has been linked to various systemic infections, including appendicitis, chorioamnionitis, osteomyelitis, pericarditis, and brain abscesses.” #ISOGG #DNA #epigenetics #colorectalcancer #cancer

https://pmc.ncbi.nlm.nih.gov/articles/PMC12522427/

“The pharmacological approach in this study, however, uses a pharmacologic agent (P7C3-A20) that enables cells to maintain their proper balance of #NAD+ under conditions of otherwise overwhelming stress, without elevating NAD+ to supraphysiologic levels.” #ISOGG #DNA #geneadons https://case.edu/news/new-study-shows-alzheimers-disease-can-be-reversed-achieve-full-neurological-recovery-not-just-prevented-or-slowed-animal-models

“By using state-of-the-art DNA techniques and newly published genomes, we were able to determine the ancestry of the Beachy Head Woman with much greater precision than before,” William reveals.” #ISOGG #DNA #AncientDNA #BeachyHeadWoman #UK #geneadons https://www.nhm.ac.uk/discover/news/2025/december/the-changing-story-beachy-head-woman.html

“If these efforts manage to pinpoint Leonardo’s Y chromosome, its sequence would become the project’s genomic ground truth. DNA recovered from other sources—such as works of art—could be measured against it, providing a powerful tool for authentication. It might also unlock genetic clues to Leonardo’s genius.” #leonardodavinci #DNA #ISOGG https://www.science.org/content/article/have-scientists-found-leonardo-da-vinci-s-dna

IGG FREE KINDLE BOOK! #igg is the acronym for “Investigative Genetic Genealogy” and this book is addictive; I already own it so highly recommend it! Use this link to get the book free on Kindle and if you don’t have a Kindle, you can read it using the Audible smartphone app. Thanks for the heads up on the free book, Thomas MacEntee
https://genealogybargains.com/amazon-chester-creek-murders
#TrueCrimeAddict #DNA #ISOGG #ArmchairDetective #FreeReads #Mystery #BookAddict #Kindle

Higher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia, whereas low-fat cheese. APOE ε4 status modified the association between high-fat cheese and AD. Our study's observational design limits causal inference” #ISOGG #DNA #epigenetics #dementia #geneadons #alzheimers #cheese #brie #cheddar #cognitivedecline https://www.neurology.org/doi/10.1212/WNL.0000000000214343

“We discovered 3 regions of the genome carrying distinct DNA methylation profiles in sperm from individuals with history of childhood psychological stress, notably at proximity of genes regulating the development of the central nervous system.” #ISOGG #DNA #epigenetics https://www.nature.com/articles/s41380-024-02872-3

“Our finding multiple high‐level and sub‐haplogroup contexts of causal mtDNA pathogenic variants in PMD patients proves that although a possible contributor, the modifying effects of haplogroup context are not a main driver of the diagnostic disparities evident for African patients.” #DNA #Haplogroup #HaplogroupL #isogg #mitochrondria #PMD #mtDNA https://pmc.ncbi.nlm.nih.gov/articles/PMC12254466/

Just finished watching the fascinating documentary “Secrets of the Neanderthals” on Netflix. Not a lot of DNA discussion but there is one part where they can identify whether the remains are male or female based on a dental protein. #DNA #ISOGG #neanderthals #Netflix #ShanidarZ #geneadons Here’s a link to the trailer: https://youtu.be/b5YtgLSU_sE?si=Ua4xg54r3hnrEdgQ

“Our findings raise the possibility that this delta–theta band oscillation could serve as a target engagement biomarker, but its relationship to food preoccupation warrants more controlled investigation," the authors of the study conclude. #DNA #ISOGG #mounjaro #zepbound #diabetes #tirzepetide #epigenetics
https://www.nature.com/articles/s41591-025-04035-5

“In individuals with adequate TRPM7 function, Mg supplementation increases the abundance of C. maltaromaticum and F. prausnitzii.” #DNA #ISOGG #epigenetics #coloncancer #colorectalcancer #magnesium #TRPM7 #geneadons
https://www.sciencedirect.com/science/article/pii/S0002916525005271?via%3Dihub

“Researchers have linked the death of a 47-year-old man in New Jersey to alpha-gal syndrome, which usually starts with a bite from a lone star tick. The man died four hours after eating a hamburger. NBC News’ Anne Thompson.” #ISOGG #epigenetics #AlphaGal #tick #allergy #AlphaGalSyndrome #meatallergy #lonestartick #geneadons

https://youtu.be/Tp96QZfzNlU?si=XZo3sUhpU8hrGtZh

“The study showed a statistical association with low and high temperature exposure and increased risk of all-cause and cardiovascular death in patients with heart failure.” #DNA #ISOGG #geneadons #epigenetics
https://www.yahoo.com/news/articles/researchers-issue-warning-discovering-unexpected-010500614.html

“The researchers hope that by targeting FTL1, future therapies may not only improve natural cognitive decline, but will also benefit people with neurodegenerative diseases.” #DNA #ISOGG #Alzheimers #epigentics #cognitivedecline #neutrites #geneadons

https://www.yahoo.com/news/articles/scientists-found-hidden-switch-brain-133000421.html

“Many systemic challenges to the brain can be mitigated by the phytochemical sulforaphane (SF), which is important in supporting mitochondrial function. SF or its biogenic precursor glucoraphanin, from broccoli seeds or sprouts, can confer neuroprotective and cognitive benefits via diverse physiological and biochemical mechanisms. SF is able to cross the blood–brain barrier as well as to protect it, & it mitigates the consequences of destructive neuroinflammation.” #ISOGG https://www.mdpi.com/2072-6643/17/8/1353

“Depression is linked to overly rigid brain circuits that resist change, and by softening these circuits and altering how their mitochondria function, fluoxetine may create a window of plasticity or flexibility in the brain. #DNA #ISOGG #Prozac #brain #geneadons #cognitive #Epigenetics
https://www.technologynetworks.com/neuroscience/news/antidepressant-fluoxetine-promotes-brain-plasticity-in-key-cells-reshaping-their-energy-systems-405046

“The new study examined DNA from the teeth of 13 French soldiers buried during the retreat in a mass grave in Vilnius, Lithuania. (The grave was discovered during construction in 2001.)” #DNA #ISOGG #Napolean #French #geneadons
https://news.yahoo.com/articles/dna-reveals-killed-napoleons-soldiers-150000382.html

“Until causative agents are identified and diagnostic tests developed, NCGS remains a diagnosis of exclusion, requiring careful systematic evaluation.” #DNA #ISOGG #geneadons #epigenetics #gluten #FODMAPS https://www.unimelb.edu.au/newsroom/news/2025/october/gluten-sensitivity-its-not-actually-about-gluten

“Their findings suggest that Chiari Malformation Type 1, a serious and sometimes fatal neurological condition, may be linked to Neanderthal genes that entered the human gene pool through interbreeding tens of thousands of years ago.” #DNA #ISOGG #geneadons #Neanderthal #ChiariMalformationType1 #AncientDNA #epigenetics https://www.sfu.ca/sfunews/media/media-releases/2025/07/interbreeding-with-neanderthals-may-be-responsible-for-modern-da.html

“The pediatric neurologist was studying whether leucovorin could help autistic children with cerebral folate deficiency — or a shortage of vitamin B9 in the brain. Researchers believe up to 70% of autistic children have antibodies that block the transport of folate into the brain, leading to these deficiencies and contributing to speech delays and behavioral challenges.” #ISOGG #DNA #autism
https://nypost.com/2025/10/14/health/my-nonverbal-autistic-son-began-speaking-at-8-with-leucovorin/