Kids (~10 yrs) with Disruptive Behavior Disorders show reduced #NucleusAccumbens activity during monetary reward anticipation ( #ICYMI , #FMRI , #ABCD , #MIDTask , #neuroscience , #neurophenotyping )...
https://psychiatryonline.org/doi/full/10.1176/appi.ajp.2020.19101092
+ "To our surprise, the task model parameters, the beta estimates of the task condition regressors , were equally if not more predictive of behavioral differences than all Functional Connectivity measures." ! (wish they tested on #MIDtask hi vs. low incentive reaction times)
-Zhao et al (2023) Neuroimage...
#MetaAnalysis confirmation of blunted #striatal activity during #reward anticipation in #schizophrenia, associated with diminished motivation, possibly reduced by atypical antipsychotic treatment (#replication , #MIDtask , #neuroscience , #neurophenomics ):
Deep bow to Matt Lieberman (@social_brains@twitter.com) for successfully nurturing _Social, Cognitive and Affective Neuroscience_ to its college years -- check out his characteristically visionary swan song here (even mentions the #MIDTask !, #neuroscience , #affectiveneuroscience):
https://academic.oup.com/scan/article/19/1/nsad080/7510584
More evidence that individuals with #schizophrenia (and their relatives) show blunted #FMRI responses during #reward anticipation in the #VentralStriatum
( despite #multiband factor=8! , #neuroscience , #NAcc , #MIDTask )
Encouraging validation and extension of earlier work linking blunted neural anticipatory reward response (#FMRI) to #ADHD in a large adolescent sample (#ABCD, #MIDTask):
https://www.sciencedirect.com/science/article/pii/S2451902223003191
Pleased to see that the #preproof of "Blunted neurobehavioral loss anticipation predicts relapse to stimulant drug use" is up on the #BiologicalPsychiatry website! Big thanks to lead authors Leili Mortazavi and Kelly MacNiven, as well as helpful reviewers (summary figure below, #neuroscience, #addiction, #neuroimaging, #MIDtask):
https://www.sciencedirect.com/science/article/pii/S0006322323014877
More evidence for blunting of neural responses during reward anticipation in schizophrenia, association with low motivation ( #ICYMI, #metaanalysis, #MIDTask, #neurophenotype ):
https://www.nature.com/articles/s41398-022-02201-8
Lovely video explainer about using #FMRI to visualize reward anticipation with the Monetary Incentive Delay Task (#MIDTask), courtesy @kingscollegelondon:
https://www.youtube.com/watch?v=z_n3QALr2ls
Nucleus Accumbens (#NAcc) activity during reward anticipation blunted in children with two parents with alcohol use problems (versus one or none) in two large longitudinal samples (#FMRI, #MIDtask):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320357/
Acute cannabis blunts monetary #reward anticipation in the #NAcc of both adolescents and adults (d~.50; from @m_wall’s gang, #MIDtask):
https://www.sciencedirect.com/science/article/pii/S2451902222002506
