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Of note to psychotherapists, social workers, and other mental health professionals, this report highlights a biological mechanism that may influence cognitive aging. Researchers describe a protein, DMTF1, whose enhancement may restore the regenerative capacity of neural stem cells, supporting memory and learning despite age-related damage. Such findings broaden the understanding of brain aging and point toward potential future interventions that slow or reverse aging-related cognitive decline.

Article Title: Scientists discover protein that rejuvenates aging brain cells

Link to Science Daily Mind-Brain News: https://ift dot tt/q2O96AQ

#neuroscience #brainaging #neuralstemcells #DMTF1 #cognitivehealth

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#NeuralStemCells (NSCs) & ependymal cells (ECs) are derived from #RadialGlialCells. This study uses #scRNAseq to characterize cell fate trajectories in the developing #VentricularZone, identifying TFEB as a regulator of the NSC/EPC balance @PLOSBiology https://plos.io/3HbrsJG

Top: CD133 showed specific enrichment on the apical surface of radial glial cells (RGCs) in the developing ventricular zone (VZ) from postnatal day 0 (P0) to P15. Ciliary membrane marker (ARL13B) and the ciliary microtubule marker acetylated-tubulin (ac-TUB) indicated ependymal cell (EPC)-lineage differentiation. Cell proliferating marker (Ki67) and neural stem cell (NSC)-lineage marker (ASCL1) indicated NSC-lineage transition. The framed region was further magnified to show details. The boundary between lateral ventricle (LV) and VZ was denoted by the yellow dotted line for better distinguishing ciliary ac-TUB and cytoplasmic ac-TUB in (B). The scale bars are 20 μm. Bottom: A model illustrating how TFEB functions in the process of bGPC specification during VZ development.

Quiescent hippocampal #NeuralStemCells (NSCs) support #neurogenesis in adulthood. This study shows that NSCs have different levels of quiescence & that Sox5 controls the balance between shallow & deep quiescence during hippocampal development @PLOSBiology https://plos.io/44Su34u

Top: DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Image credit: Cristina Medina-Menéndez. Bottom: Summary of NSC quiescence dynamics during early postnatal DG development (left) and their alterations in Sox5null mice (right).

Quiescent #NeuralStemCells (qNSCs) in the adult mouse SVZ have a limited capacity to generate #glia. This study shows that a subpopulation of multipotent qNSCs with high Gas1 expression can produce #oligodendrocytes throughout life & after demyelinating injury @PLOSBiology https://plos.io/4iY4nbh

Top left: Representative IF co-labeling of Nestin and tdT (DsRed) in the E15.5 VZ/SVZ. Top right: Representative IF co-labeling of Ki67 and tdT (DsRed). The dashed line roughly marks the ventricular zone. Middle: Representative Sox2 IF staining in the VZ/SVZ of wild-type (left) and Gas1 KO (right) mice at P0.5. The dashed lines roughly mark the boundary of VZ/SVZ. Bottom: Schematic summarizing the developmental origin and function of the Gas1high NSC subpopulation.

🔬Its been 17 years since Dr. Sally Temple and Dr. Jeffrey Stern opened the first independent stem cell research institute in the country! Since opening, they have continued to foster the successful translation of neural stem cell discoveries to therapeutics!

Learn more about our institution and ongoing research at https://zurl.co/sBj9

#stemcellresearch #neuralstemcells #agerelatedmaculardegeneration #alzheimersdisease #parkinsonsdisease #spinalcordinjury

🐣 Our April issue is online today!

This month's cover highlights an article on #ShearStress control of vascular leaks and #atheromas.

Also in this issue: articles on #BreastCancer, #NeuralStemCells, #PrematureOvarianInsufficiency, #Psoriasis, #CLN1, & much more!

🗞️ Fully #openaccess: https://www.embopress.org/toc/17574684/2023/15/4

In Part 3 of her year-end blog series, Dr. Liz Fisher details publications authored by NSCI scientists in 2022, relating to #neuralstemcells, #neurodegeneration, #organoid and #assembloid nomenclature, #SpinalCordInjury, #intrabody therapeutics and more.

https://neuralsci.org/sharing-science

#NeuralStemCells

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