Lmst

#PROS1

In #Science (@sciencemagazine) this week, the Hanahan lab shows that the #RNA-binding protein #FMRP enables #tumors to evade being attacked by #CD8TCells. It does so by both suppressing #CCL17 & promoting #Tregs via #IL33 & #M2 #macrophages via #PROS1 & #ExtracellularVesicles!

https://bit.ly/Sci_abl7207

#CancerImmunology #RBP

"Up-regulated FMRP expression and activity are involved in an immunosuppressive program in cancer cells (upper left) that renders tumors impenetrable, creating so-called immune deserts (upper right). By contrast, its absence is associated with a reprogrammed tumor microenvironment that recruits and activates T lymphocytes, producing inflamed tumors, including CD8 T cells (red immunostain; lower right) with consequently beneficial immune destruction. Tregs, regulatory (immunosuppressive) T cells"

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