She also talked about the formation of coacervates based on #DNA or #RNA as well as #peptides and their potential involvement in early life. https://www.nature.com/articles/s41467-025-64335-9

She also talked about the formation of coacervates based on #DNA or #RNA as well as #peptides and their potential involvement in early life. (2/2) www.nature.com/articles/s41... #ChemSky #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids

Differential stability and dyn...

Interesting @biorxivpreprint.bsky.social@bsky.brid.gy by the group of Matt Disney. They used fully functionalized fragments to enrich their targets and identify their binding sites on #RNA. Interesting insights into preferential binding to UTRs and the construction of RiboTACs. www.biorxiv.org/content/10.1...

biorxiv.org/content/10.110...

Interesting bioRxiv preprint by the group of Matt Disney. They used fully functionalized fragments to enrich their targets and identify their binding sites on #RNA. Interesting insights into preferential binding to UTRs and the construction of RiboTACs.

https://www.biorxiv.org/content/10.1101/2025.11.05.686775v1
#NucleicAcids #TargetedDegradation #Chemistry #ChemBio

A few retrospective impressions of last wednesday's hands-on presentation of the Rechenkraft.net #AugmentedReality visualization system for molecular objects (a.k.a. #HoloDeck) - this time, as part of the #parasitology seminar at the Institute for Parasitology of the Justus Liebig University #Gießen.

Below you can see a few images showing the full ready-to-play setup of 4 #HoloDeck / #TiltFive systems - prior to the start of the workshop.

#MINT #STEM #AR #VR #bioinformatics #protein #DNA #RNA

📣 Workshop announcement: This year's SILVA 🧬 online workshop will take place on 🗓️ 11th December, at 3pm CET.
The SILVA team will inform about the upcoming release, the new website design 🖥️, and more! We look forward to discussing SILVA developments with you.

Write to contact@arb-silva.de to receive the Zoom login details

#DSMZDigitalDiversity #RNA #database #FAIRdata

How to fix genetic ‘nonsense’: versatile #RNA gene-editing tool could tackle a host of diseases

“Chemical biologist David Liu dreamt up a new gene-editing tool while preparing for ‘science karaoke’, an event at which each member of his team presents an out-of-the-box idea that could send their lab in a new direction.”

https://www.nature.com/articles/d41586-025-03770-6

RNA Book Of The Month

Nature’s Best Hope by Douglas W. Tallamy

Tallamy’s first book, Bringing Nature Home, awakened readers to an urgent situation: wildlife populations are in decline because native plants are fast disappearing. His solution? Plant more natives. In this new book, Tallamy envisions a grassroots approach to conservation. Nature’s Best Hope shows how homeowners can turn their yards into conservation corridors that provide wildlife habitats.

#RNA #ReligiousNaturalism #Bookstodon

Groundbreaking discovery from Italian researchers at University #LaSapienza: they’ve uncovered how genetic and epigenetic mechanisms, driven by #Notch3 protein and #RNA modification, fuel a rare pediatric leukemia (T-cell ALL).

This insight could revolutionize targeted therapies, improving outcomes for youngest patients.

Precision medicine is the future,
stop using #AI for bullsh*t,
use it for this.

#PediatricLeukemia #Genetics #CancerResearch #NHS

🦣🔬 Researchers at #Stockholm University and University of #Copenhagen achieved the first successful #RNA sequencing from woolly #mammoth tissue, breaking records with 39,000-year-old genetic material from a juvenile named Yuka.

The RNA revealed Yuka's correct gender, muscle function details, and molecular evidence of cellular stress during the mammoth's final moments.

👉 https://www.livescience.com/animals/mammoths/mammoth-rna-sequenced-for-the-first-time-marking-a-giant-leap-toward-understanding-prehistoric-life

#genetics #prehistoric #science #dna #research #biology

Mammut-Jungtier liefert weltweit älteste RNA. Paläogenetiker isolierten erstmals 39.000 Jahre alte RNA aus einem Permafrost-Mammut. #Mammut #RNA #Permafrost #Genetik #Dextinction
https://www.scinexx.de/news/biowissen/mammut-jungtier-liefert-weltweit-aelteste-rna/

🧬 Is it possible to uncover RNA–protein interactions despite limited experimental data?

🔗 RNA-protein interaction prediction without high-throughput data: An overview and benchmark of in silico tools. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.015

📚 CSBJ: https://www.csbj.org/

#RNA #ProteinInteraction #Genomics #Proteomics #Bioinformatics

"A young woolly mammoth now known as Yuka was frozen in the Siberian permafrost for about 40,000 years before it was discovered by local tusk hunters in 2010. The hunters soon handed it over to scientists, who were excited to see its exquisite level of preservation, with skin, muscle tissue, and even reddish hair intact. Later research showed that, while full cloning was impossible, Yuka’s DNA was in such good condition that some cell nuclei could even begin limited activity when placed inside mouse eggs."

https://arstechnica.com/science/2025/11/worlds-oldest-rna-extracted-from-ice-age-woolly-mammoth/

#rna #biology #mammoth

14-Nov-2025
The world’s oldest #RNA extracted from #woollyMammoth

https://www.eurekalert.org/news-releases/1105073 #science #fossils #ancientDNA #evolution #extinction #geneExpression #genome

#Paläontologie

*Fun facts: #Sibirien:*
(2/2)

...eine vollständige #Klonung zwar unmöglich war,
#Yukas #DNA jedoch in so gutem Zustand war, dass einige Zellkerne sogar eine begrenzte
Aktivität aufnehmen konnten, wenn sie in Eizellen von Mäusen eingebracht wurden.
Nun ist es einem Team gelungen, Yukas #RNA zu sequenzieren – eine Leistung, die viele Forscher einst für unmöglich gehalten hatten. "

//

RNA-Moleküle gelten als besonders empfindlich gegen schnellen Abbau. Bei #Pflanzen scheint's anders: Sie „dekorieren“ ihre Blattoberflächen gezielt mit #RNA und steuern damit die Zusammensetzung ihres Mikrobioms … Mehr Details zur Studie gibt's hier 👉 https://www.laborjournal.de/editorials/3371.php #Mikrobiom #PlantBiology

🧬 Is RNA folding the next frontier for generative AI?

🔗 Transformers in RNA structure prediction: A review. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.03.021

📚 CSBJ: https://www.csbj.org/

#RNA #Bioinformatics #ComputationalBiology #MachineLearning #StructuralBiology #AI #DeepLearning #Biophysics #Genomics

🪲 Sprayable RNA pesticide works best when potato beetles are small

https://phys.org/news/2025-10-sprayable-rna-pesticide-potato-beetles.html

#insects #beetles #agriculture #farming #agronomy #biotech #pesticides #rna #cornell

🧬 Hidden patterns link ribosomal RNAs to genes of the nervous system

https://medicalxpress.com/news/2025-10-hidden-patterns-link-ribosomal-rnas.html

#biology #molbio #rna #brain #neuroscience #genetics #ribosomes #health #disease

Unser Heft 11/2025 ist raus!
Titelthema: Kunst trifft Wissenschaft

Außerdem:
- Serien Premiere des Elfenbeinwurms❗
- Methoden Special #RNA-Sequenzierung
- #Tierversuchspolitik;
- Pathologie;
- Forschungsförderung;
- Sättigungspillen;
- t-RNA #Chaperone
- Thermostabile #Polymerasen;
- …
Das ganze Heft online: https://www.laborjournal.de/rubric/aktuell/index.php