Not bad for boosting 5.1 movie volume, which is never mixed to stereo properly by any media player or television I've used (always have to turn up the volume to even remotely hear the speaking parts, then frantically dig around for the remote once the swell of music or explosions start):
sox -S .\audio.wav audio-amp.wav remix -m 1,3,4,5 2,3,4,6 gain -n
Anyone got any handy Sox or other CLI commands to fix podcasts, video audio with very variable volume? This works pretty well, but I can't add my usual 'gain -n' at the end because it seems to introduce a few odd spikes through the file.
sox -S .\audio.flac .\audio-com.flac compand 0.3,1 6:-70,-60,-20 -18 -90 0.2
#sox #sox2 #dynamicrangecompression #compressor #audioprocessing
Повстанцы бессмертия: Как банда безумцев превратила смерть из судьбы в выбор
Они называли их безумцами. Сегодня — у них бюджеты в миллиарды. Генная терапия, химическое перепрограммирование, эпигенетика — это уже не фантастика, а клиника. В 2025 году человечество в упор смотрит на смерть... и начинает дёргать её за бороду. Это манифест повстанцев бессмертия. История тех, кто отказался стареть.
https://habr.com/ru/articles/923842/
#iPSC #Oct4 #Sox2 #Klf4 #cMyc #биоинформатика #биотехнологии #генетика #молекулярная_биология #SENS
α⧸ω ST phosphorylation diagrams for human and mouse sex-determining region Y (Sry) box-containing 2 (#SOX2:p). Named back-in-the-day when a transcription factor pretty much had to have "box" in its name somewhere, both sequences have a prominent S+phosphoryl acceptor near residue 250. Human has an additional S+phosphoryl adjacent to the nward high mobility group domain. The absence of this acceptor in mouse is probably an artifact caused by a hard-to-observe tryptic peptide. #proteomics
Very interesting dissection of the #enhancer landscape of the #Sox2 locus using a powerful gene modification platform:
Synthetic regulatory genomics uncovers enhancer context dependence at the Sox2 locus - https://doi.org/10.1016/j.molcel.2023.02.027
