Lmst

#cullin

Online now - our 2023 issue 5:
Activation of #plant #NLR #immune receptors
#Stereoisomer specificity in #flagellin #sialylation
Dormant #ribosome activation by #TORC1
#Cytomegaloviral #DCAF for #cullin-mediated #STAT2 degradation
Cover: Korolchuk lab
https://www.embopress.org/toc/14602075/2023/42/5

This cover highlights the article NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy by Tetsushi Kataura, Viktor I. Korolchuk and colleagues. Better together: human autophagy receptor NDP52 evolved the ability to form disulphide-linked chains which initiate the formation of an autophagosome around damaged mitochondria. Teaming up of NDP52 receptors allows mitophagy to be switched on faster and more efficiently in humans compared to other mammals that lack this mechanism.(Scientific image by Hanna Salmonowicz, IMOL Institute, Warsaw)

Viral mimicry of a #DCAF #ubiquitin #ligase adaptor: #CryoEM shows how rodent #cytomegalovirus #CMV E27/M27 hijacks host cell #CRL4 #cullin-RING E3s to degrade #STAT2 and suppress #antiviral #interferon signaling
https://www.embopress.org/doi/10.15252/embj.2022112351

Schematic visualization of the article's synopsis

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