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#prototrophy

Victoria Stuart 🇨🇦 🏳️‍⚧️persagen
2023-09-08

Emergent biosynthetic pathway to essential amino acids by metabolic metathesis
biorxiv.org/content/10.1101/20

* alkene metathesis unknown in extant biochemistry
* alkenic amino acid vinylglycine can be generated in biocompatible reaction
* vinylglycine produced in situ then used as precursor of isoleucine & methionine
* allows growth of Escherichia coli strains normally requiring these essential amino acids

Title: Emergent biosynthetic pathway to essential amino acids by metabolic metathesis Fig. 1: image of Petri plates (agar growth / selection medium); extracellular and intracellular biosynthetic patways involved. Source: https://www.biorxiv.org/content/10.1101/2023.09.06.556532v1.full.pdf

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