Leiden Early Drug Discovery & Development (LED3) is a hub of scientists working on early drug discovery at the Leiden Institute of Chemistry, the Leiden Academic Centre for Drug Research, the Institute of Biology Leiden and the Leiden Institute of Advanced Computer Science.
RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
Great @LED3hub Lecture by Anne Osbourn of the John Innes Centre. She talked about the amazing diversity of plant natural products, the gene clusters for their synthesis and their recombinant production for applications in #food and #health.
We are very happy that Anne Osbourn from the John Innes Centre visited us today for a LED3 Lecture. She talked about "Harnessing plant metabolic diversity for food and health applications".
#Plants #NaturalProducts #GeneClusters #DrugDiscovery #ChemBio #Chemistry #Food #Health
Are you interested in cutting-edge research in Early Drug Discovery and Development?
We have an amazing program for our LED3 Lectures for the remaining months of this academic year. Make sure to check out the program and mark your calendars for the talks that you want to attend!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
We are looking forward to the LED3 Lecture of Anne Osbourn on January 29th She will talk about "Harnessing plant metabolic diversity for food and health applications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
Our dean Jasper Knoester addresses our Science Faculty in his New Year's speech. Interesting insights into the future strategic goals of our faculty and great to hear him highlight the priority themes including the @LED3hub with new theme leader Mario van der Stelt.
https://www.universiteitleiden.nl/en/science/led3
Cellular profiling of kinases: The group of Mario van der Stelt of our @LED3hub with first authors Joel Ruegger and Berend Gagestein published CellEKT for profiling of the cellular targets of kinase inhibitors. There is a lot of potential in profiling the selectivity of this important drug class, which is further developed in the company Omivera (https://omivera.com/) by Anthe Janssen, Joel Ruegger and Zoe Voggelaar. (3/12)
https://www.sciencedirect.com/science/article/pii/S1535947625000593
Efficiently screening for protein binders: The group of Sebastian Pomplun of our @LED3hub developed self-encoded libraries (SELs) that allow affinity-selection MS-based screening of protein binders from >500,000 member libraries in a single experiment without the need for a barcode. Very excited to follow further, how these methods enable identification of binders for high-value targets. (6/12)
https://www.nature.com/articles/s41467-025-65282-1
New antibiotic for Clostridioides difficile infections: The groups of Nathaniel Martin of our @LED3hub and of Wiep Klaas Smits of the LUMC published the powerful semisynthetic guanidino lipoglycopeptide EVG7 to treat Clostridioides difficile infections. While I saved #antibiotic discovery for last, there is surely still a high need for new antibiotics, may they be natural products, semisynthetic derivatives or fully synthetic compounds. (11/12)
https://www.nature.com/articles/s41467-025-64067-w
Exciting news that the FDA has approved the first oral GLP-1 agonist for clinical use for Novo Nordisk.
https://www.novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=916472
It was amazing to hear about the science behind these medications directly from Lotte Bjerre Knudsen in her @LED3hub Lecture.
Excited to be part of the @LED3hub and of the organizing committee of the #LED3Lectures and #LED3Symposium. I am convinced that these are amazing initiatives that strengthen our collaborative spirit. New exciting activities are coming in 2026 and 2027.
We heard insightful LED3 Lectures by Paola Picotti, Andrea Rentmeister, Jeff Kelly, John Overington, Kim Lewis, Ed Tate, Jay Keasling, Willem Velema, Nicolas Winssinger and Lotte Bjerre Knudsen. (3/3)
#DrugDiscovery #Chemistry #Biology #PharmaceuticalSciences #ChemBio
We are happy that we could continue our activities to bring our researchers closer together including the LED3 PhD/Postdoc Symposium #LED3Symposium and our flagship #LED3Lectures, in which we heard talks by a diverse selection of world-leading speakers in the field of #DrugDiscovery. (2/3)
Another exciting year for our LED3 hub comes to a close. We were able to celebrate many successes including awarded grants, accepted publications, received awards and newly started companies. 2025 also marks the year, in which the activities of LED3 were formalized in the priority theme "Drug Discovery and Development" of our Faculty of Science at Leiden University. (1/3)
Interesting article by the American Peptide Society about the recent publication by the group of Sebastian Pomplun of our @LED3hub on using BindCraft to predict #peptide binders to high value protein targets.
https://americanpeptidesociety.org/aps-news/binders-by-design/
Congratulations to the three LED3 researchers that were awarded NWO XS grants to drive their science forward:
Madeline Kavanagh - Inhibiting the growth of brain tumours
Margo Dona - Rapid personalised treatment for anaplastic thyroid cancer
Sandra Irmisch - Producing rare substances for medicines
https://www.universiteitleiden.nl/en/news/2025/12/open-competition-doman-science-xs-grants-for-leiden-researchers
#Chemistry #ChemBio #DrugDiscovery #Cancer #Medicines
New Publication from our LED3 hub!
The group of Sebastian Pomplun published "ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors" in the journal Chem.
https://www.sciencedirect.com/science/article/pii/S2451929425004309?via%3Dihub
Interesting paper by the group of Sebastian Pomplun of our @LED3hub. Chemical stapling of recombinant proteins on the example of the Myc inhibitor Omomyc leads to enhanced serum stability, cellular uptake and intracellular activity.
https://www.sciencedirect.com/science/article/pii/S2451929425004309?via%3Dihub
Jessica Hoang (supervised by Kim Bonger and Martijn Verdoes of the Leiden University Medical Center)
Lars van Abswoude (supervised by Mario van der Stelt, Monique Mulder and @Stephanhacker2)
(4/4)
