New work from our lab!
G3BP1-dependent mechanism suppressing protein aggregation in Huntington’s models and its demise upon stress granule assembly

https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddac304/6972256?utm_source=advanceaccess&utm_campaign=hmg&utm_medium=email

Here we explored whether stress granules influence Huntington’s disease-related changes. We found that induction of stress granules triggers the accumulation of pathological aggregates in Huntington’s disease models.

@CECAD @UniKoeln

#introduction (2)
And here a link to our website: http://www.davidvilchezlab.com/
and also a video about our lab: https://youtu.be/kalsrf1ZbQ0

I’m still not sure how this 🐘 works, but I guess the best is to start with an #introduction
Here I will be posting about stuff from our lab at the CECAD. We want to understand #aging and #proteostasis to prevent multiple age-related diseases such as #ALS, #Alzheimer, #Parkinson and #huntington

@TheVilchezLab

David, great to see you here! 🙂 Welcome to #ScienceMastodon!

#agingreserarch #cellbiology #celegans #cecad #biology

@cilib thanks Bernhard! I’m still not sure how this works 😅