About to finish #PhD in molecular microbiology/virology? Join us as #postdoc at the BSRC in St Andrews and work with Michael Nevels and me to study mechanisms underlying the devastating synergy of #GroupAStrep and #ChickenPox co-infections. Full details: https://www.vacancies.st-andrews.ac.uk/Vacancies/W/4582/0/391937/889/research-fellow-ar2823mr

I'm thrilled to share that I have been promoted to Professor @UniofNewcastle! I'll be Chair of Structural Microbiology from 1st August 2023. Looking forward to continue my research in @nubiosciences 1/

I'd like to thank my amazing team, particularly @barwinskasendra whose amazing work and support has been key.

New article! Read The Streptococcus pyogenes vaccine landscape https://www.nature.com/articles/s41541-023-00609-x?utm_source=dlvr.it&utm_medium=mastodon in npj Vaccines

We recently trialled the Direct Electron Apollo on our JEOL CryoARM 300. We collected test data on TMV at several magnifications. I processed one dataset to 1.85 angstroms resolution. The map is available at EMDB - EMD-16572, and the raw data are at EMPIAR -11404. Data collected at the Scottish Centre for Macromolecular Imaging by chief microscope wrangler James Streetley. Virus prepared by Andrew Love’s group at the Hutton Institute.

Absolutely fascinating review: The elements of life: A biocentric tour of the periodic table, by Kaleigh Remick and John Helman.

https://www.sciencedirect.com/science/article/pii/S0065291122000339

Finally got around to trying #modelangelo - wow.
Three chains build into a boxed asymmetric unit of a virus capsid resolved to 2.5 angstroms. Some minor tinkering to get to a pretty comprehensive and accurate model ready for refinement - and fast. Thanks @SjorsScheres

Useful for those among us starting teaching again next month https://rushkoff.medium.com/how-to-grade-papers-written-by-ai-4277a78a892 ping @cristyclark

The value of surrounding yourself with people with different perspectives…making the impossible possible: a basketball exemplar.

RT @TansuYegen@twitter.com

I watched already 10 times. How did Klay get the ball🧐

🐦🔗: https://twitter.com/TansuYegen/status/1611125045434421249

Hi Mastodon, I'm here too!
I am an illustrator who specializes in communicating complex topics in a playful manner. I do this both for my personal work and for MinuteEarth.
Looking forward to hanging out with all of you in this new platform :)

Hello! I’m a recently appointed lecturer in Biomolecular NMR at the UCL School of Pharmacy. My group develops NMR methods and software for the analysis of molecular interactions and dynamics, and we apply these to study protein folding, misfolding and quality control, and ligand binding. Always open to collaborations. Creator of NMR TITAN. Advocate for #julialang. Outside of the lab, greyhound owner, amateur pianist, horn player, opera lover, cyclist and swimmer. #introduction #NMRchat #lgbt

📢 PhD position available! 📢

Come join my group at UCL and develop methods to characterise dynamics in large molecules and anti-microbial peptides. Help us get the most from new ultra-high field spectrometers!

* Deadline 26th Jan 2023 *

Project details: https://ucl-epsrc-dtp.github.io/2023-24-project-catalogue/projects/2228bd1103.html

Use the project code 2228bd1103 to apply here:

https://www.ucl.ac.uk/epsrc-doctoral-training/prospective-students/apply-ucl-esprc-dtp-studentship

@nmrchat @structbio @chemistry

The sun’s performance gets a low grade due to brevity, a mere 6h52min in the East Neuk of Fife today. I am also done with my work for the day and year, all exam scripts marked. Holiday mode activated 🥃.

Looking for a PhD studentship? We have a fully funded @DiMeN_DTP position available in our team @MM_Sheffield studying phage biology and structure. We will use bacterial genetics and cryoEM (with Prof Per Bullough) to understand how phage kill C. difficile. Although some background in molecular biology, biochemistry, microbiology or structural biology would be useful, you'll receive full training from our groups.

https://www.findaphd.com/phds/project/mrc-dimen-doctoral-training-partnership-towards-phage-therapy-combining-genetics-and-cutting-edge-cryoem-to-optimise-a-superbug-killing-virus/?p150635Xl
Deadline January 13th

Our final submission of the year. More to come in 2023! https://www.biorxiv.org/content/10.1101/2022.12.20.520977v1?rss=1

#ArtAdventCalendar day 20: wash your hands...

I was asked to do this for a #Catholic #microbiologist friend of mine about 5 years ago. I finally got around to it!

I'm not sure I personally agree with it... But different strokes for different folks!

Hello! I am an MRC CDA fellow in the Pharmacology department at the University of Cambridge. Me and my research group are fascinated by the molecular mechanisms that underlie protein self-assembly. We work on strategies to prevent amyloid formation and we are using engineered biomolecular condensates to gain insights into how Nature utilises phase separation to facilitate protein degradation. #neurodegeneration #BiomolecularCondensates #proteindegradation #introduction #Proteindesign

Why are bacterial biofilms tolerant to antibiotic treatment? In our new preprint, we show how phage liquid crystalline droplets in P. aeruginosa biofilms protect bacteria from antibiotics.

https://www.biorxiv.org/content/10.1101/2022.12.13.520211v1

German words to show the importance of capital letters:

wagen - to dare
Wagen - car, cart

reifen - to mature
Reifen - tire

ahnen - to suspect
Ahnen - ancestors

arm - poor
Arm - arm

reich - rich
Reich - empire

samt - together with, along with
Samt - velvet

weg - away, gone
Weg - way, path

bar - cash
Bar - bar, pub

elf - 11
Elf - elf

fest - hard
Fest - Party

And no: "Party hard" is not "Fest fest". That would be too easy.

Enjoy our language!

#TheGermanWord

Hey Structural Biologists :protein:

#crystallography #MX #CryoEM #CryoET #NMR #SAXS #HDX #Alphafold #PDB #EMDB #StructuralBiology

I have created a group @strucbio .

If you tag this account in any relevant toot, it will automatically boost it.

So if you follow this account, any toots about structural biology should end up in your TL. The more people use it, the better it will be.

Boosting appreciated. :protein:

We used all the microscopes for this one! If you thought inclusion bodies are the only respiratory syncytial virus induced cellular compartments - then we have some news. Outstanding work from Swetha Vijayakrishnan and Andrew Burns. Thanks to our fantastic collaborators Rachel Fearns, Phil Santangelo and Becky Dutch - and their awesome labs. Finally thanks to the amazing scientists at Diamond Light Source, eBIC and B24 beam lines. https://www.biorxiv.org/content/10.1101/2022.11.28.517999v1