Lmst

Wild Flowers Festival at Frozen Head State Park #stateparks
#TN with Tennessee Native Plant Society (Larry Pounds)
#TNPS

Frozen Head State Park, Tennessee

@SFGravel @alxsim thank you!!! your review on usage of UMAP in population genetics was extremely useful in my own work on A. thaliana. I wish there is more awareness of pros and cons of these non-linear techniques in the field of scRNA-seq.

Gautam Shirsekar boosted:

On Friday,
@diazale successfully defended a wonderful thesis on modelling high-dimensional genetic data. A must-read if you are working with UMAP or genetic clustering, or if you just like well-written and thoughtful scientific writing. Congratulations!

Gautam Shirsekar boosted:

@alxsim @coevolution
You can find it here: https://github.com/diazale/phd_thesis.
My understanding is that the S t-SNE refers to the fact that we are considering distances between neighbouring points as drawn from a distribution, and we are trying to align low- and high-dimensional distributions. In principle one could use this to estimate uncertainty in representation, but the truth is that the "best" representation is so hard to find, due to many local minima, that other sources of uncertainty dominate.

Use of t-SNE and #UMAP is increasing in biology! So I wonder how stochasticity of both the algorithms affect how we interpret the results? Can somebody enlighten? (#tSNE at least makes it clear in its acronym that it is stochastic)

Gautam Shirsekar boosted: