Key events in the discovery of inhibition.

Fishell & Rudy 2011.

https://doi.org/10.1146/annurev-neuro-061010-113717

#Neuroscience

RT @rubykong92
1/5. Wanna know the RSFC behavioral prediction comparison between parcellations🧠 and gradients🌈? Our paper is officially out https://doi.org/10.1016/j.neuroimage.2023.120044
We predict behavioral measures in HCP and ABCD datasets with optimized resolutions for different approaches.

Monkey Dorsolateral Prefrontal Cortex Represents Abstract Visual Sequences during a No-Report Task - Journal of Neuroscience

TL;DR This article discusses how monkey dorsolateral prefrontal cortex represents abstract visual sequences during a no-report task. The study found that monkey DLPFC monitors abstract visual sequential information potentially with different dynamics in the two hemispheres.

Linked by @DesrochersLab (13⭐)

Monitoring sequential information is an essential component of our daily lives. Many of these sequences are abstract, in that they do not depend on the individual stimuli, but do depend on an ordered set of rules (e.g., chop then stir when cooking). Despite the ubiquity and utility of abstract sequential monitoring, little is known about its neural mechanisms. Human rostrolateral prefrontal cortex (RLPFC) exhibits specific increases in neural activity (i.e., “ramping”) during abstract sequences. Monkey dorsolateral prefrontal cortex (DLPFC) has been shown to represent sequential information in motor (not abstract) sequence tasks, and contains a subregion, area 46, with homologous functional connectivity to human RLPFC.

#lotd #science

Network Neuroscience

Creativity at Rest: Exploring Functional Network Connectivity of Creative Experts
https://direct.mit.edu/netn/article-abstract/doi/10.1162/netn_a_00317/115621/Creativity-at-Rest-Exploring-Functional-Network/

Mathematician and aerospace engineer Mary Jackson was born #OTD in 1921. She worked at the National Advisory Committee for Aeronautics until it was succeeded by NASA in 1958. Jackson then became the first Black woman to work as a NASA engineer.

Bio: https://www.nasa.gov/content/mary-w-jackson-biography
Image: NASA

nature medicine

Beautiful work by @yetianmed
@AndrewZalesky
@DrBreaky

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
https://www.nature.com/articles/s41591-023-02296-6

Machine learning can easily produce false positives when the test set is wrongly used. Just et al in
@NatureHumBehav suggested that ML can identify suicidal ideation extremely well from fMRI and we were skeptical. Today retraction and our analysis of what went wrong came out.

Here is the retracted paper: https://nature.com/articles/s41562-017-0234-y and here is our refutation https://nature.com/articles/s41562-023-01560-6. If true, the paper's approach could revolutionize psychiatric approaches to suicide.

So what went wrong? The authors apparently used the test data to select features. Obvious mistake. A reminder for everyone into ML: never use the test set for *anything* but testing. Only practical way to do so in medicine? Lock away the test set till algorithm is registered.

Side note: it took 3 years to go through the process of demonstrating that the paper went wrong. Journals need procedures to accelerate this. Also, all the good things of this were by
@tdverstynen

RT @dora_hermes
Our new paper on the speed of cortico-cortical signaling just came out today in @NatureNeuro

https://www.nature.com/articles/s41593-023-01272-0

With @DorienBlooijs @Kai_J_Miller and collaboration with @UMCUtrecht

Be like @frankgarcea

He knows how to rock.

Pavlov's Dogz at the 30th Annual Cognitive Neuroscience Society meeting. Saturday, March 25, 9:30pm

#George Samandouras @gsamandouras Intraoperative stimulation mapping of thalamocortical tracts in asleep and awake settings: novel electrophysiological, anatomical, and tractographic paradigms https://pubmed.ncbi.nlm.nih.gov/36708535/

This year, I published #TheBlackAgendaBook.

I'm really proud of it and all the voices that spoke to issues impacting our country. I'm also indebted to so many for a successful debut. I want to thank anywhere that loans out or sells books, my conversation partners, and all the readers.

One way to support this book is to purchase it by and throughout #BlackHistoryMonth!

#BlackMastodon #academia #econtwitter #economics #mastodon #mastoart #books #book

Buy it here! https://t.co/I7ZOT0wu9R

R.I.P. Mark

Get Stoke(s)d!
Journal of Cognitive Neuroscience (2022) 35 (1): 1–3.
https://doi.org/10.1162/jocn_e_01938

Tribute to Mark Stokes.
I was saddened to learn of the passing of my colleague Mark Stokes. Here is a video tribute I recorded for his festschrift in June 2022.
https://youtu.be/CpNLvFDMbhI

#neuroscience

The Stroop effect involves an excitatory–inhibitory fronto-cerebellar loop
https://www.nature.com/articles/s41467-022-35397-w

#neurosciene

SIPS 2023 will be held from June 22-24, 2023 in Padua, Italy. We are excited to gather again in-person and online! The meeting will allow both virtual and in-person participants to fully participate in the conference.
https://www.improvingpsych.org/SIPS2023/

The aim of the SIPS conference is to generate ideas, goals, and actionable plans to improve psychological science. The meeting will have a dynamic agenda of very brief presentations, hackathons, open discussions, workshops, social events, and more.

One neat finding is that lesions involving the striatum were associated with selection performance across all tasks. This opens up a lot of interesting future work to understand the subcortical contributions to action selection and tool use. For example, some of my group’s current work investigates tool use in persons undergoing sEEG for epilepsy monitoring.

I’m excited for what’s ahead and will continue to update the pre-print as reviewer feedback rolls in.

Thanks for tuning in!

We then used support vector regression lesion-symptom mapping analyses to identify the lesion sites associated with abnormal performance across the tasks. We found that adjacent but largely independent lesion sites were associated with abnormal action selection across the tasks.

We correlated measures of response selection (high conflict performance controlling for low conflict performance) between the tasks. We found only weak correlations between tasks, suggesting that the mechanisms contributing to the selection of hand postures for tool use may be distinct from those involved in mapping a stimulus onto its motor response.

We asked: Does a common mechanism support the selection of manual responses regardless of the content being selected? If so, we hypothesized there would be correlations between tool action selection performance and performance in two stimulus-response mapping tasks: the Eriksen flanker task and the Simon task.

When using a tool, one needs to select an appropriate hand posture to manipulate the object. After left hemisphere stroke, persons with limb apraxia can be impaired when asked to select between tool actions when gesturing tool use.