Assistant Professor #UCLA
#NKcells #Innateimmunity #CatDad
Views are my own
Check out our papers recent highlight and some of our commentary with Salon.com
@gpollara @ImmunologyKing Very interesting!
@ImmunologyKing Thank you! I also saw a talk about sexual dimorphism in ILC2 responses, so wouldn't be surprised to see this in ILC3s as well.
We have recently found that #NK cell effector function is sexually dimorphic. How? Female NK cells in mice and human express higher levels of the epigenetic regulator #UTX, which escapes X-linked inactivation. UTX regulates the chromatin accessibility of #IFNg and #Csf2, making female NK cells more potent in response to #cytokines and #viral infection.
"Here, we have identified a population of innate lymphocytes that we term tissue-resident memory-like natural killer (NKRM) cells. In response to murine cytomegalovirus infection, we show that circulating NK cells were recruited in a CX3CR1-dependent manner to the salivary glands where they formed NKRM cells, a long-lived, tissue-resident population that prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells."
Schuster et al @ImmunityCP
#Immunology #NKCells #ImmuneRegulation
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
@ImmunologyKing @halama_immuno Yes likely context dependent signals in different tissues. RAG2-/- mice still have NK cells with similar phenotype in adipose. Important not to confuse these with ILC1 though.
@ImmunologyKing @halama_immuno We also find similar cells in human liver and adipose, how do they get there??
Protecting #tissues from #autoimmunity is a fascinating function of the immune system: in this new work on #innateimmunity in the salivary gland it is #lymphoid #NKcells that regulate #TCells and prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells. These NK cells show adaptive-like features with long-term residency in non-lymphoid tissues. #immunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
We now know that circulating #NK cells can become tissue-resident following infection. Function is to limit #autoimmunity through #TRAIL mediated elimination of CD4+ T cells in sites of viral persistence. Team science is the best science!
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
@RauchLab
This is so stupid. How do our older peers expect science to continue if they set impossible standards on early career PIs?
Happy to collaborate on this study profiling the existence and development of cross-tissue #ILC1 in humans.
https://doi.org/10.1016/j.celrep.2022.111937
Key Takeaways:
-Human ILC1 are rare in healthy liver, but accumulate in cirrhotic livers.
-Unknown #LSEC-derived signals + #TGFβ1 + #il7 drive differentiation of ILC progenitors to ILC1.
-Human #NK cells do not differentiate to ILC1 under multiple conditions ex vivo.
-Human ILC1 make #il2 but functional relevance of this still unknown.
Pretty convincing article on peer review. One thought, I don’t know if we (‘we’ being the science world collectively) know how to communicate to the public that some “research” is engineered to be biased (think AEI, CATO reports, contract research) while others are independent. Peer review has given independent researchers a powerful tool to limit the influence of special interests. https://experimentalhistory.substack.com/p/the-rise-and-fall-of-peer-review
A big congrats to Dr. Andrew Hildreth on passing his thesis defense! #PhDone
@stokel yes
Fiona Watt (Head of EMBO) "speaks from the heart" at #RecognizingPreprintReview describing the phenomenon where post-docs tread water for months waiting for a journal to accept a paper, often having to do more experiments. She advocates recognizing refereed preprints in fellowship applications to allow them to move on i.e. stop #publishorperish
Twitter, at the moment, is like going to a holiday get together with your family. Yeah, there are some cool people there and you get to see some folks you miss and have interesting surface-level conversations with them, but there are also racists and fascists and someone trying to rope you into a pyramid scheme.
Mastodon is coming home afterwards and meeting up with your friends and decompressing with people you choose to hang with, in pajama pants and a hoodie.