Interesting paper by the groups of X. Lu, L. Zhou and Y. Sun in @angewandtechemie.bsky.social. #ABPP data guides warhead and target selection for lysine-directed DNA-encoded libraries with squaramides, salicylaldehydes and nitrobenzyl alcohols. (1/2) #ChemBio #Chemsky onlinelibrary.wiley....
#ABPP
Interesting paper by the groups of X. Lu, L. Zhou and Y. Sun in Angewandte Chemie. #ABPP data guides warhead and target selection for lysine-directed DNA-encoded libraries with squaramides, salicylaldehydes and nitrobenzyl alcohols. (1/2) #ChemBio #Chemistry https://onlinelibrary.wiley.com/doi/10.1002/anie.202505581
#FocusOnCovalentDrugs is off to a great start with an inspiring talk by Marcus Bantscheff. He talked about the various #chemoproteomics technologies that his group is applying to better understand the targets of small molecule drugs. Interesting insights into #ABPP and #TPP. (1/2) #chemsky #ChemBio
#FocusOnCovalentDrugs is off to a great start with an inspiring talk by Marcus Bantscheff. He talked about the various #chemoproteomics technologies that his group is applying to better understand the targets of small molecule drugs. Interesting insights into #ABPP and #TPP. (1/2)
#Chemistry #ChemBio
The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio
The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors. #ABPP #ChemSky #ChemBio
Looking forward to the #ABPP2025 meeting in London starting this weekend. An amazing lineup of world-leading speakers in the field from academia and industry!
If you are there on Saturday or Sunday morning and want to catch up, send me a message!
#ABPP #ChemBio
www.eventcreate.com/e/abpp2025/
ABPP2025: The 14th Internation...
Looking forward to the #ABPP2025 meeting in London starting this weekend. An amazing lineup of world-leading speakers in the field from academia and industry!
If you are there on Saturday or Sunday morning and want to catch up, send me a message!
He then zoomed in on protein S-palmitoylation as the main modification that his group is interested in. In this context, he introduced the power of #ABPP to study this modification. (3/5) pubs.acs.org/doi/full/10....
S-Palmitoylation during Retino...
He then zoomed in on protein S-palmitoylation as the main modification that his group is interested in. In this context, he introduced the power of #ABPP to study this modification. (3/5) https://pubs.acs.org/doi/full/10.1021/acs.jproteome.3c00151
Inspiring keynote lecture by Uwe Grether of Roche at the #Lunteren meeting of the #SOC and #MCCB divisions of KNCV. He talked about the impressive story of developing MAGL inhibitors into the clinics through a huge diversity of technologies including #ABPP, #AI, #LSF and #HTE.
Inspiring keynote lecture by Uwe Grether of Roche at the #Lunteren meeting of the #SOC and #MCCB divisions of KNCV. He talked about the impressive story of developing MAGL inhibitors into the clinics through a huge diversity of technologies including #ABPP, #AI, #LSF and #HTE.
If you are interested in Activity-Based Protein Profiling, check out my starter pack on Past and present members of the Ben Cravatt lab! Recent additions include: @alansaghatelian.bsky.social @hsinyulee.bsky.social @mads-chem.bsky.social #ABPP #ChemBio #chemsky go.bsky.app/LZR93i3
If you are looking for exciting scientific content (with a focus on #ChemBio, #Chemistry, #ABPP, #ChemicalProteomics) over on bluesky, check out these starter packs:
short list: https://go.bsky.app/C4URhFa
pack 1: https://go.bsky.app/3SyoVNw
pack 2: https://go.bsky.app/9keb2TP
If you are looking for exciting scientific content (with a focus on #ChemBio, #ChemSky, #ABPP, #ChemicalProteomics), check out these starter packs:
short list: go.bsky.app/C4URhFa
pack 1: go.bsky.app/3SyoVNw
pack 2: go.bsky.app/9keb2TP
RE: https://bsky.brid.gy/convert/ap/at://did:plc:boqurhtatdnbwptajoso3r4z/app.bsky.graph.starterpack/3lb57rhdc662w
Interesting preprint @biorxivpreprint by the group of @DanNomura. They put an electrophilic handle on the CDK4/6 inhibitor Ribociclib and show that it converts it into a #proteindegrader #TPD. Using #ABPP #ChemicalBiology, they identify RNF126 as responsible E3 ligase. Furthermore, they identify a minimal motif engaging RNF126 and use it to convert various protein ligands into degraders for e.g. CDK4, BCR-ABL and c-ABL, PDE5, BRD4, AR and AR-V7, BTK, SMARCA2, and LRRK2. https://doi.org/10.1101/2022.11.04.512693
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