#AnimalModel

2023-08-18

Hatchling to adult in five months, the new 🐌 regime is working šŸ˜€! Almost an animal 'model'.
#Cepaea #animalmodel #snails

2022-12-09

Over the past decades, scientists have used #animalmodel to study @muscleregeneration, which is regulated by #stemcell s. These animal models have been very helpful in understanding the mechanisms of muscle #regeneration, but they don't always accurately reflect the same range of diseases that humans experience. Therefore, researchers have suggested creating reliable in vitro models using human muscle cells.

2022-12-09
2022-11-30

Interdisciplinarity in research and what can go wrong:

Diving back into animal model lit, and this paper on the advent of knockout mice and how molecular biologists and animal behavior specialists worked together (or not) is excellent:
Nelson, N. (2015). A Knockout Experiment: Disciplinary Divides and Experimental Skill in Animal Behaviour Genetics. Medical History, 59(3), 465-485. doi:10.1017/mdh.2015.30

#Interdisciplinarity #AnimalModel #AnimalBehavior #HistoryOfScience

Screenshot of the PDF of the paper A Knockout Experiment: Disciplinary Divides and Experimental Skill in Animal Behaviour Genetics

Quick #introduction,

I’m a French #Anesthesiologist and #intensivist working in cardiac surgery in Paris. Passionate with #ECMO and #machineperfusion and their crosstalk with other organs and systems. Learned #animalmodel in Brisbane with Pr John Fraser and #clinicalresearch with Pr Alain Combes.

#PhD is tomorrow so wish me luck!

2022-11-08

How do we #scientists and #academics buit #models that provide useful information? And how do we make sure that we're not holding on to models that are no longer useful? I'm picking up some work in #AnimalModel building and evaluation that I'd published some years back, closely related to #PhilosopyOfScience and diving back into what's new in the field. Time to stretch the brain again!
Flow chart on #model #evaluation from behavioralandbrainfunctions.bi

Flow chart describing how to evaluate animal models based on ethical and scientific criteria, including a number of pathways leading to variants of "abandon the model" as possible outcome, along with various forms of validity.
2021-12-04
Considering mice are required to be used in most studies to get grant funding and only have 20% of the human pathways, this is huge.
♲ @ScienceMagazine@twitter.com:
The humble pig has substantial and growing potential as an accurate, core #AnimalModel for humans, according to a Review in @ScienceTM that discusses the current status and future applications of pigs in translational biomedical research. fcld.ly/efdwm63

Client Info

Server: https://mastodon.social
Version: 2025.04
Repository: https://github.com/cyevgeniy/lmst