Golly. That sure sounds a whole lot like POTS, doesn't it?

https://pubmed.ncbi.nlm.nih.gov/1691782/#:~:text=Recombinant%20human%20C5a%20(rhC5a)%20caused,ventricular%20contractility%2C%20and%20coronary%20vasoconstriction.

#POTS
#C5a
#LongCovid
#Covid

Longhaulers should petition for access to this molecule. It will help. Very interesting the way it works. Both sources describe it better than I could myself, so I'll just point you in their direction.

Popular:
http://www.dicyt.com/viewNews.php?newsId=32527

In depth: https://www.researchgate.net/publication/268197277_Targeting_the_minor_pocket_of_C5aR_for_the_rational_design_of_an_oral_allosteric_inhibitor_for_inflammatory_and_neuropathic_pain_relief

#LongCovid
#C5a
#C5aInhibitor
#GPCR
#Covid

If you'd like to know how SARS-CoV-2 damages the mitochondria of cells that aren't even infected by the virus, this is the most likely mechanism: overstimulation of C5aR1 with C5a.

80% of Longhaulers carry biomarkers consistent with chronic Complement over-activation. Exertion compounds the rate at which C5a is produced via the Alternative Pathway of Complement, making #C5a good candidate for the agent responsible for Post Exertional Malaise in Long Covid and ME CFS.

https://pubmed.ncbi.nlm.nih.gov/31624141/

What bastards. Too crowded my ass. They knew what they had and did not want it to compete with other markets.

https://pubmed.ncbi.nlm.nih.gov/31447248/

This drug can probably be used to avert C5a driven cytokine storms. Probably help CFS sufferers, too.

#PharmaPhuckery
#hC5a
#C5a
#Carprofen