Cambridge-based Maxion Therapeutics raises €68.9 million in Series A funding led by General Catalyst to advance its KnotBody pipeline targeting ion channel and GPCR-driven diseases.Maxion Therapeutics, a Cambridge-based biotech firm, has raised €68.9 million in a Series A funding round led by General Catalyst. #biotech #drugdevelopment #funding #GPCR #ionchannels
#GPCR
"Direct effect of membrane environment on the activation of mGluR2 revealed by single-molecule FRET" in #Structure
🔗 https://doi.org/10.1016/j.str.2025.01.011
🧵 #GPCR #mGluR🧼#detergents #cholesterol
🔬 #smFRET
💻🧪 #MD #mutants
Congrats to C. Banerjee, B. Liauw, and R. Vafabakhsh!
Check our new preprint !
Triple orthogonal labeling with 2 unnatural aminoacids + 1 SNAP-Tag for 3 color #smFRET.
We resolve a new intermediate in the activation of metabotropic glutamate receptor 2.
https://biorxiv.org/content/10.1101/2024.10.31.621373v1
Collaboration with Jean Philippe Pin & Philippe Rondard (IGF Montpellier) & Don Lamb (LMU Munich)
Biophysicists at #UniLeipzig demonstrate mechanism of #signalling by adrenaline-binding #receptor at atomic level. In the future, researchers could use the results to avoid side effects when developing drugs.
#GPCR @SFB1423
Biophysicists at #UniLeipzig demonstrate mechanism of #signalling by adrenaline-binding #receptor at atomic level. In the future, researchers could use the results to avoid side effects when developing drugs.
#GPCR @SFB1423
Biophysiker der #UniLeipzig weisen Mechanismus der #Signalübertragung durch Adrenalin-bindenden #Rezeptor auf atomarer Ebene nach. Mit den Ergebnissen könnten Forschende künftig Nebenwirkungen bei #Entwicklung von Wirkstoffen umgehen.
#GPCR @SFB1423
The version of record of our #Nematostella #GPCR #neuropeptide paper has now been published
https://elifesciences.org/articles/90674#content
For #cnidarian #neuroscience there are lots of new deorphanised receptors described in the paper. We also identified orthologs across cnidarian species, including corals, #Exaiptasia etc. so the resource is not limited to Nematostella.
New study shows that the C-terminal fragment of the #GPCR #muscarinicM2receptor, translated from an #IRES, localizes to the #mitochondrial inner membrane & is upregulated upon stress exposure, reducing respiration & #ROS to protect cells #PLOSBiology https://plos.io/3Uomtb8
For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look!
#BC007 ist ein potenzieller Wirkstoffkandidat gegen das #PostCovidSyndrom und andere #Autoimmunkrankheiten mit funktionellen Autoantikörpern gegen #GProtein gekoppelte Rezeptoren #gpcr Es handelt sich um ein #aptamer das diese krankmachenden #Autoantikörper blockieren soll. Die klinische Phase-II-Studie reCOVer der Augenklinik des #Uniklinikums #Erlangen untersucht den molekularen Weg bestimmter Autoantikörper beim Post-COVID-Syndrom. In diesem Zusammenhang startet in …
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Longhaulers should petition for access to this molecule. It will help. Very interesting the way it works. Both sources describe it better than I could myself, so I'll just point you in their direction.
The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd
GproteinDb update brings new G protein- #GPCR couplings, AlphaFold2-multimer models, interface interactions and coupling selectivity analysis
https://t.co/goZcFihoeX
Research reveals molecular mechanism of asymmetric #calcium_sensitive #receptor activation.
https://phys.org/news/2023-11-reveals-molecular-mechanism-asymmetric-calcium-sensitive.html
The November Issue of @CellChemBiol is Online! Read it at: https://www.cell.com/cell-chemical-biology/current?utm_source=dlvr.it&utm_medium=mastodon #chemicalbiology #GPCR #RAF #STING #SARSCOV2 #ASO #PDL1 #HDAC #indoxylsulfate #E3ligase #UPS10 #targetID #luciferin #forwardgenetics
#Glucagon #receptor structures uncover new #arrestin interaction mechanism.
#signalling #transduction #GPCR
https://phys.org/news/2023-08-glucagon-receptor-uncover-arrestin-interaction.html
First preprint about my work at Schrödinger:
We show how to predict ligand efficacy via absolute binding free energy perturbation on different receptor conformations — confirming and utilizing the principle that the functional response of a receptor is mainly determined by the thermodynamics of ligand binding.
https://chemrxiv.org/engage/chemrxiv/article-details/64b1cccaae3d1a7b0db45aa8
#FEP #FreeEnergy #LigandEfficacy #GPCR #DrugDiscovery #DrugDesign #Thermodynamics #GPCRs #BindingFreeEnergy
Our favourite #Platynereis #opsin now in the mammalian brain as a new #optogenetic tool!
"Here we ... found that the Platynereis dumerilii ciliary opsin ... is an efficient, versatile, light-activated bistable GPCR that can suppress synaptic transmission in mammalian neurons with high temporal precision in-vivo "
In Editors' Choice in Science Signaling, I highlight a study by Park, Martemyanov, Garcia-Marcos, and colleagues revealing another level of bias in GPCR signaling. In the context of neurotransmission, the authors showed that the protein GINIP bound to GTP-bound Galphai subunits, preventing them from interacting with their effectors. As a result, signaling by Gbetagamma subunits was enhanced, biasing the response to GPCR stimulation. Read my summary here: https://www.science.org/doi/10.1126/scisignal.adj6131 #science #gpcr
Previously, only one #GPCR with a ligand was known in #cnidaria, the receptor for the #Clytia Maturation-Inducing-Hormone. This receptor was found by Gonzalo Quiroga Artigas and Philipp Bauknecht in our lab, in a collaboration with Evelyn Houliston.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000614
#cnidaria #neuropeptide #evolution #neuroscience
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