#DevBio
“for now, fetal tissues are needed to provide a benchmark for the complex tissues and interactions between cells in organs…Restricting fetal tissue research will slow the progress of the alternatives that all parties want and need.”
#Science #DevBio #Research #MedMastodon #Medicine
https://www.nature.com/articles/d41586-026-00308-2
Song et al. discover and characterize three co-opted/captured ERV envelope gene clades, revealing that each plays a distinct and critical role in neural regulation, reproductive maturation, and viviparity in vertebrates.
I love the cover of the latest issue of Development @Co_Biologists
As Alex Eve posted over on Bluesky: "the latest cover helps to remind us that Development is not just a faceless brand of a journal eager to line shareholder pockets - it's a group of people who share a love for #devbio and, in my experience, really are trying to do their best for their community."
25 years of Xenbase. https://www.xenbase.org/xenbase/doNewsRead.do?id=1042 #science #devbio #xenopus #frogs
NXR Bioinformatics Workshop: April 18-26, 2026. The workshop format will be a wet-dry-hybrid exercise, specifically emphasizing single-cell analysis. https://www.xenbase.org/xenbase/doNewsRead.do?id=1041 #science #devbio #xenopus #frogs
And the open access article in Genes and Development
#Science #DevBio #EmbryonicDiapause #Reproduction
https://genesdev.cshlp.org/content/early/2025/12/11/gad.353143.125.abstract
“cells switched on a set of genes that act as natural brakes on the MAP kinase pathway, which normally pushes stem cells to commit to specific fates. When the researchers turned off these "brakes," the cells quickly lost their pluripotency and began showing signs of becoming specialized cell types, confirming that this braking system is essential for maintaining the diapause-like state.”
#EmbryonicDiapause #Science #DevBio
https://www.rockefeller.edu/news/38808-some-mammals-can-hit-pause-on-a-pregnancy-understanding-how-that-happens-could-help-us-treat-cancer/
“present an extensive single-cell and spatial multi-omic atlas of the human reproductive tract during prenatal development”
Very nice.
#Science #Development #DevBio #ReproductiveTract #ReproSky
Drs. Halley-Stott, Hörmanseder, Jullien, and Pasque wrote a perspective on Sir John Gurdon about his mentorship and impact. Published in Nature Communications. https://www.xenbase.org/xenbase/doNewsRead.do?id=1040 #science #devbio #xenopus #frogs
Hello, here is a review I wrote about how cells sometimes try to synchronise with surrounding cells so that they can do a good job of building tissues during development. It is called "Keeping up with the neighbours"
https://link.springer.com/article/10.1038/s44319-025-00662-8
Apply for Development's Pathway to Independence (PI) programme, supporting postdocs in #devbio and #stemcell research during the transition to their first group leader position: https://www.biologists.com/grants/development-pathway-independence
Application deadline: 2 February 2026.
Ran et al. generated a retinal regeneration model and a tumor model using targeted integration in X. tropicalis (PNAS). Kagawa et al. provide a step-by-step protocol for knock-in targeted integration in X. laevis (DGD). https://www.xenbase.org/xenbase/doNewsRead.do?id=1032 #science #devbio #xenopus #frogs
Xenopus Conference 2025 - Check out the video of the 20th International Xenopus Conference held at the Univeristy of Portsmouth August 17-21st, 2025. https://www.youtube.com/watch?v=plxxiD0UYu4 #science #devbio #xenopus #frogs
Cold Spring Harbor Laboratory Course - Cell & Developmental Biology of Xenopus: Gene Discovery & Disease, April 7 - 21, 2026. Application Deadline: January 16, 2026 https://xenbase.org/xenbase/doNewsRead.do?id=1030 #science #devbio #xenopus #frogs
Prof. Sir John Gurdon (1933-2025). It is with great sadness that I share the news of the death of a father of the Xenopus field, Professor Sir John Gurdon. https://www.xenbase.org/xenbase/doNewsRead.do?id=1029 #science #devbio #xenopus #frogs
You can now search the entire EvoDevo Papers database (~1.8k posts). Check it out on the website https://evodevo.brunovellutini.com or read more here: https://brunovellutini.com/posts/evodevo-papers-search/
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4
Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors