And the open access article in Genes and Development
#Science #DevBio #EmbryonicDiapause #Reproduction
https://genesdev.cshlp.org/content/early/2025/12/11/gad.353143.125.abstract

“cells switched on a set of genes that act as natural brakes on the MAP kinase pathway, which normally pushes stem cells to commit to specific fates. When the researchers turned off these "brakes," the cells quickly lost their pluripotency and began showing signs of becoming specialized cell types, confirming that this braking system is essential for maintaining the diapause-like state.”
#EmbryonicDiapause #Science #DevBio
https://www.rockefeller.edu/news/38808-some-mammals-can-hit-pause-on-a-pregnancy-understanding-how-that-happens-could-help-us-treat-cancer/

“present an extensive single-cell and spatial multi-omic atlas of the human reproductive tract during prenatal development”

Very nice.
#Science #Development #DevBio #ReproductiveTract #ReproSky

https://www.nature.com/articles/s41586-025-09875-2

Drs. Halley-Stott, Hörmanseder, Jullien, and Pasque wrote a perspective on Sir John Gurdon about his mentorship and impact. Published in Nature Communications. https://www.xenbase.org/xenbase/doNewsRead.do?id=1040 #science #devbio #xenopus #frogs

Hello, here is a review I wrote about how cells sometimes try to synchronise with surrounding cells so that they can do a good job of building tissues during development. It is called "Keeping up with the neighbours"

https://link.springer.com/article/10.1038/s44319-025-00662-8

#DevBio

Apply for Development's Pathway to Independence (PI) programme, supporting postdocs in #devbio and #stemcell research during the transition to their first group leader position: https://www.biologists.com/grants/development-pathway-independence

Application deadline: 2 February 2026.

#science #devbio #xenopus #frogs

Ran et al. generated a retinal regeneration model and a tumor model using targeted integration in X. tropicalis (PNAS). Kagawa et al. provide a step-by-step protocol for knock-in targeted integration in X. laevis (DGD). https://www.xenbase.org/xenbase/doNewsRead.do?id=1032 #science #devbio #xenopus #frogs

Xenopus Conference 2025 - Check out the video of the 20th International Xenopus Conference held at the Univeristy of Portsmouth August 17-21st, 2025. https://www.youtube.com/watch?v=plxxiD0UYu4 #science #devbio #xenopus #frogs

Cold Spring Harbor Laboratory Course - Cell & Developmental Biology of Xenopus: Gene Discovery & Disease, April 7 - 21, 2026. Application Deadline: January 16, 2026 https://xenbase.org/xenbase/doNewsRead.do?id=1030 #science #devbio #xenopus #frogs

Prof. Sir John Gurdon (1933-2025). It is with great sadness that I share the news of the death of a father of the Xenopus field, Professor Sir John Gurdon. https://www.xenbase.org/xenbase/doNewsRead.do?id=1029 #science #devbio #xenopus #frogs

You can now search the entire EvoDevo Papers database (~1.8k posts). Check it out on the website https://evodevo.brunovellutini.com or read more here: https://brunovellutini.com/posts/evodevo-papers-search/

#EvoDevo #DevBio #EvoBio

Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4

https://www.nature.com/articles/s41467-025-63806-3

#DevBio #StemCells

Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors

https://www.biorxiv.org/content/10.1101/2025.05.15.654369v2

#DevBio

Calling early-career developmental biologists!

Apply for a funded place at our Workshop, Novelty, Co-option and Divergence During Gene Network Evolution, taking place next June.

Application deadline: 5 December

https://www.biologists.com/workshops/june-2026/

#Biology #Workshop #DevBio #DevelopmentalBiology #BiologistsWorkshops #Research #Collaboration #Networking #Network #Community

Very excited to have our back-end-of-an-embryo cell-neighbour-analysis featured as today's Biomedical Image of the Day!

Congrats to first author and ace image-analyst Matt French!

https://bpod.org.uk/archive/2025/9/16

#DevBio

Excellent piece and interview with Anaïs Bailles about the self-organizing powers of Hydra:

Hydra are a cosmos in a cuvette: https://www.reviewertoo.com/hydra-anais-bailles/ (by Elise Cutts)

#Hydra #SelfOrganization #TissueMechanics #DevBio #Biology #Physics

Naert et al. (Nature Biotechnology) present Pythia editing enabling predictable, accurate genome editing in diverse cellular contexts, both in vivo (Xenopus and adult mouse brains) and in vitro. https://www.xenbase.org/xenbase/doNewsRead.do?id=1028 #science #devbio #xenopus #frogs

‪Development‬'s Issue 16 is complete!

On the cover: Embryonic eye of an anole lizard stained for nuclei and F-actin. The image was acquired at the 2025 MBL Embryology course by Arthur Boutillon and was the Editor's choice from the Node image competition.

https://journals.biologists.com/dev/issue/152/16

#Development #DevelopmentalBiology #DevBio #Biology #EmbryonicEye #Academia #Publishing #Research #Journal

Hello :) The peer-reviewed version of our cephalic furrow paper is out:

Patterned invagination prevents mechanical instability during gastrulation https://doi.org/10.1038/s41586-025-09480-3

Back-to-back with:

Divergent evolutionary strategies pre-empt tissue collision in gastrulation https://doi.org/10.1038/s41586-025-09447-4

And a commentary piece:

Flies evolved a shock-absorber tissue used during embryonic development https://doi.org/10.1038/d41586-025-02532-8

#Drosophila #Diptera #Morphogenesis #Evolution #EvoDevo #DevBio #TissueMechanics