Auf dem Güterring ist irgendwie mehr los... Beim Warten auf die S-Bahn. #Schnellzuglokomotive #E11013 #Leipzig #LLT #eisenbahn #Museumslok

When technology meets mathematics: The A100 GPU powers the discovery of the latest giant in the prime number world! 🚀💻✨🔍💡🧮💥🎉

The "new" largest prime was discovered today (October 21, 2024)! It's a Mersenne prime \( (2^p-1 )\), which is easier to find because it can utilize a specialized "faster" primality test (known as LLT, i.e., Lucas-Lehmer test). On October 11, an NVIDIA A100 GPU in Dublin, Ireland, reported that M136279841 is probably prime. On October 12, an NVIDIA H100 in San Antonio, Texas, USA, confirmed primality with a Lucas-Lehmer test.

\[\Huge 2^{136,279,841}-1\]

It took nearly 6 years for the Great Internet Mersenne Prime Search (GIMPS )software to find it after the previous largest known prime. It was also the first Mersenne prime found using GPUs.

#Prime #PrimeNumber #LargestPrime #LargestKnownPrime #MersennePrimeA100 #TensorCore #LLT #LucasLehmerTest #PrimalityTest #GPGPUs #GIMPS

https://www.mersenne.org/primes/?press=M136279841
https://www.livescience.com/physics-mathematics/mathematics/largest-known-prime-number-spanning-41-million-digits-discovered-by-amateur-mathematician-using-free-software
https://www.popularmechanics.com/science/math/a62695223/biggest-prime-number/
https://www.popsci.com/science/largest-prime-number/
https://www.smithsonianmag.com/smart-news/amateur-mathematician-discovers-the-largest-known-prime-number-with-more-than-41-million-digits-180985321/
https://www.newscientist.com/article/2452686-amateur-sleuth-finds-largest-known-prime-number-with-41-million-digits/
https://www.sciencefocus.com/news/new-prime-number
https://sherwood.news/culture/new-largest-prime-number-discovered-by-former-nvidia-software-engineer/
https://www.tomshardware.com/tech-industry/former-nvidia-engineer-discovers-41-million-digit-prime-largest-prime-number-known-to-man-was-uncovered-and-verified-with-the-help-of-gpus
https://www.washingtonpost.com/science/2024/10/23/nvidia-prime-mersenne-gpu-cloud/
https://gizmodo.com/nvidia-computer-finds-largest-known-prime-blows-past-record-by-16-million-digits-2000514948
https://fermatslibrary.com/p/6883b84b
https://en.wikipedia.org/wiki/Lucas%E2%80%93Lehmer_primality_test
https://en.wikipedia.org/wiki/Great_Internet_Mersenne_Prime_Search
https://en.wikipedia.org/wiki/Probable_prime
https://en.wikipedia.org/wiki/Largest_known_prime_number

Sagas
(1987) : Garcia-Molina, Hector Salem, K...
DOI: https://doi.org/10.1145/38714.38742
#design #recovery #sagas #concurrency #LLT #database #long_lived_transaction #my_bibtex

Sagas
(1987) : Garcia-Molina, Hector Salem, K...
DOI: https://doi.org/10.1145/38714.38742
#concurrency #LLT #database #design #recovery #long_lived_transaction #sagas #my_bibtex

Sagas
(1987) : Garcia-Molina, Hector Salem, K...
DOI: https://doi.org/10.1145/38714.38742
#recovery #design #long_lived_transaction #concurrency #sagas #database #LLT #my_bibtex

Sagas
(1987) : Garcia-Molina, Hector Salem, K...
DOI: https://doi.org/10.1145/38714.38742
#concurrency #LLT #database #sagas #recovery #long_lived_transaction #design #my_bibtex

Statin revisited.

❤️‍🔥 statin vs no-statin: 25% RRR MACE
❤️‍🔥 intense statin vs less intensive: addl 15% RRR
❤️‍🔥 high intensity statin w/⬇️50mg/dL achieved = 28% RRR MACE
3/ #llt

trying to understand why another provider told a young MI <55 yrs of age pt to stop their statin+eze and “just go with repatha, because it works better”.

Fourier and Odyssey were incremental add-on tx to baseline statin, ADDing RRR of 15%. https://link.springer.com/article/10.1007/s40119-020-00163-w #llt

#PAD - the forgotten #ASCVD component.

🦵🏾MI/CVA events higher in PAD than in prior MI/CVA pts!!!!
🦵🏾Low use of statins/other LLT in PAD 👀😮
🦵🏾#LLT effective in PAD: statinize!

#acc23

In an era of increased awareness surrounding #APOB, are we measuring this more and how does is relate to LDL-C?

@ldjande3 leading out on @Intermountain data. #acc23 #llt @KirkKnowlton

Fantastic work by my colleague, 2nd year internal medicine resident Dr Stephanie Skove - Complex Cases #CvPrev #LLT

Why we #acc23

present, discuss, learn

#clearoutcomes
🫀subgroups - yay benefit in women
🫀benefit seen in 1° 👀👍🏾 as well as 2°
🫀benefit in diabetes 🙌🏾🙌🏾

Important CVOT adding #BempedoicAcid into the hall of MACE reducing #LLT.
#acc23 #HeartPA #PhysicianAssociate

Here, pt had a greater effect than anticipated (~45% reduction). Jumping to 80 mg (skipping 2 titrations) may only reduce an additional 18%.

Meanwhile, adding ezetimibe 10 mg could potentially drop LDL-C by 20% w/o risk of statin myalgia.

#LLT
https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehac709/6931821?redirectedFrom=fulltext&login=false

Adding to @SABOURETCardio #LLT posts -

Important to recognize even low(er) doses of statins have a great upfront reduction in LDL-C.

Pt w/hx of statin intolerance and LDL-C 202 mg/dL, on reinitiation (atorva 10 mg), had f/u LDL-C, 110 mg/dL.
#PhysicianAssociate #RuleOf6s

Feel free to drop in this evening, as we discuss Lipid Guideline Updates and New Therapeutics. Reach out to Riley at rroberge@heartoneaz.com for the zoom link and password.
#LLT #PA #PhysicianAssociate #HeartPA #Cardiology #PreventiveCardiology @APAC_Car…https://lnkd.in/gEWhkzK5

Younger woman (<50) with CABG following prior stent. FH+

Baseline LDL-C >190
Lp(a) >200 nmol/L

Rosuvastatin 40 mg
Praluent 150 mg/mL

Now, LDL-C <30 mg/dL😍

#knowfh #PhysicianAssociate #cvlipids #llt @KAWilemon

Reviewing #AHA22 on demand. @kewatson, thank you for your wonderful discussion on the PROMINENT trial

1) fibrates in the statin era, do not lower CV risk
2) fibrates do lower trigs, consider for pancreatitis risk
3) room for NAFLD/NASH? 🤔
#CardioTwitter #LLT

Honored to review lipid guidelines and the multitude of new/novel therapeutics for #LLT. Thank you HEART ONE ASSOCIATES LLC.
#CardioTwitter #PhysicianAssociates #ACCCVT #NursePractitioners
@APAC_Cardiology

Follow the link in the flyer:…https://lnkd.in/gfWNZTzT

Sagas
(1987) : Hector Garcia-Molina and Kenneth Salem
DOI: https://doi.org/10.1145/38714.38742
#LLT #concurrency #database #design #long_lived_transaction #recovery #sagas
#my_bibtex