#MultipleSclerosis
Nerve guide conduits offer promise for peripheral nerve regeneration, but their performance remains inferior to autologous nerve grafts. Aligned silk fibroin nerve conduits (ASNCs) were developed and their biocompatibility and regenerative potential were assessed in vitro and in vivo. Compared to RSNCs, ASNCs promoted cell adhesion and directional growth along the aligned fibers. In vivo result...
There is a close association between PTX3 and the pathogenesis and progression of neurological diseases. Review details the gene localization, protein domains, and high-resolution three-dimensional conformation of the molecule. Review also discusses the therapeutic prospects of targeting the molecule and its potential as a biomarker and therapeutic target.
Parp7 suppresses type I interferon signaling, which is crucial for tuning the innate immune response to combat pathogen invasions, fight cancer, and prevent autoimmune diseases. Inhibition of PARP7 promotes type I Interferon signalling and relieves experimental autoimmune encephalomyelitis in mice.
Neurological disorders encompass cerebrovascular diseases, neurodegenerative diseases, and autoimmune demyelinating disorders. Integrins are critical regulators of central nervous system function, making them a focal point in neurological disease research. Integrin signaling has been implicated in the pathophysiology of various neurological disorders.
I'll be running the MS Motion 10k again, a fundraising event that benefits research into the cause of MS. https://www.linkedin.com/feed/update/urn:li:activity:7361357341406990336/ #ms #multiplesclerosis #running
Adipose stem cells (ASCs) are a subset of mesenchymal stem cells with validated immunomodulatory and regenerative capabilities. Several studies on autoimmune encephalomyelitis (EAE), the animal model of MS, have clearly shown a therapeutic effect of ASCs. However, controversial data on their efficacy were obtained from I- and II-phase clinical trials in MS patients, highlighting standardization...
MiR-342 is essential for Treg cells to mitigate autoimmune inflammation in central nervous system and allergic airway inflammation in the lung.
Liposomes loaded with the tolerogenic adjuvants all‐trans retinoic acid (RA) and vitamin D3 (VD3) are injected into the skin and selectively induce CD14+ dermal DC migration and CD1a dim DC migration. Migrated DCs from RA or VD3 liposome-injected skin differentiate into FoxP3+ CD127 low and ICOS+ Tregs.
L2-a is a structurally optimized, highly selective BTKi designed to minimize drug-induced liver injury and improve blood-brain barrier permeability.
Autologous hematopoietic stem cell transplantation (aHSCT) has been shown to benefit patients with relapsing and remitting multiple sclerosis (RRMS) who have an inadequate response to DMTs. A 56-year-old Filipino female with RRMS underwent aHSCT two years ago. She has not had any relapses, is not on any DMT, has a stable EDSS score of one,
Microglia play a critical role in central nervous system (CNS) pathologies including multiple sclerosis (MS). Their modulation offers therapeutic potential especially during progressive disease courses. Sipo modulated microglia populations, increasing CD163+ CD206+ and CX3CR1+ while reducing CD86+MHC-II+. cells. Proteomic spinal
Sheng Xuexiaoban capsules (SXXCs) restored immune dysfunction in ITP model mice. SXXCs treatment significantly improved the proportion and function of Tregs.
with AM is effective in protecting nervous tissue against the demyelinating effects of lysophosphatidylcholine. SEM analysis reinforced the efficacy of AM.