Lmst

🧠 New paper by Safaai et al. (2025): parietal #cortex output populations show highly structured, task-dependent population geometry. Using multi-area recordings and circuit modeling, they show that #parietal populations display organized task-related patterns rather than uniform mixed coding, and that distinct output groups shape how decisions are routed to downstream targets:

🌍 https://doi.org/10.1038/s41593-025-02095-x

#Neuroscience #NeuralCoding #ParietalCortex #PopulationDynamics #DecisionMaking

Fig. 1: Differences in the activity of neurons projecting to distinct cortical targets.

What are the neural mechanisms behind short-term #memory errors? This study shows that they are primarily linked to a drift in neural activity in posterior #ParietalCortex, highlighting a need for stable neural representations to support accurate memory performance @PLOSBiology https://plos.io/4p85IzD

Ca2+ responses of PPC neurons during a short-term memory task. Left: The schematic illustrates the behavioral task designed to assess short-term memory in head-restrained mice. During the sample phase, black-and-white phase-reversing gratings moved either leftward or rightward (or downward or rightward) for 4 s on a screen in front of the mouse. After a 1.5- or 2-s delay, two laterally positioned lick ports were placed within reach of the mouse’s tongue. Correct licking at the corresponding lick port was rewarded with water, whereas incorrect licking resulted in a time-out as a punishment. Right: Color-coded trial-averaged ΔF/F traces of direction- and phase-selective neurons. Left Panel: neurons selective for rightward stimuli; Right Panel: neurons selective for leftward stimuli. ΔF/F values were normalized to the maximum ΔF/F and aligned based on each neuron’s time-to-peak response. Within each directional group, neurons are subdivided by phase selectivity based on GLM classification: those selective for the sample (S), delay (D), or both phases. The bottom panels display neurons that were jointly selective for both sample and delay phases (86 for rightward, 49 for leftward).

How does sensory information construct representations in the human brain? This study shows that a network including prefrontal & posterior #ParietalCortex & anterior #insula has a key role in translating perceptual information to concepts, semantics & action plans #plosbiology https://plos.io/4lbXN2b

Stimuli used for the experimental task. Complete, recognizable examples of object categories and morphed, unrecognizable versions of the same images (cupcake, zucchini, pliers, paint brush, car, cement mixer, heron, skunk). In Experiment 1, the stimuli set was composed of 40 complete images in each of the four categories. In Experiment 2, a subset of 30 complete images per category was employed. All images presented in this figure are included in the BOSS image database and written permission to employ these images in this figure has been kindly granted by the owner.

How do we decide between ambiguous options? @gvaldebenitoo @pablobilleke &co use fMRI & TMS-EEG to show that #ParietalCortex is causally involved in computational processes that underestimate uncertainty during #DecisionMaking under ambiguity. #PLOSBiology https://plos.io/3Heobpr

#ParietalCortex

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