Tomorrow, I will present some of our work on the regulation of #C3G (aka RapGEF1), an activator of #Rap1
📅March 11
🕙10am
🌎 Center for Biological Research Margarita Salas CIB #CSIC

Looking forward to the visit and meeting colleagues at CIB

(Unfortunately, no streaming)

#paper_alert
Pip5k1γ regulates axon formation by limiting Rap1 activity
Di Meo et al @lsajournal
https://www.life-science-alliance.org/content/7/5/e202302383
Impairing Pip5k1γ's function or manipulating membrane tension by osmotic shock induces the formation of supernumerary axons by a hyper-activation of #C3G & #Rap1

Paper by Ueda et al "Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1" in iScience @iScience
https://www.cell.com/iscience/fulltext/S2589-0042(23)01369-X
The role of talin1 in cell polarization, downstream of Rap1, seems to be independent of talin binding to integrins and of integrin adhesion
#Rap1 #talin #cytoskeleton #GEFs #GAPs

#introduction
Hello, this is Jose M de Pereda and I run a research group at the Center for Cancer Research in #Salamanca (Spain) (#CSIC #USAL).
We study the structural and mechanistic basis of #integrin based #CellAdhesion complexes (mostly #Hemidesmosomes) and of #Rap1 signaling. Knowing in detail how these molecular systems work is essential to understand how they are altered in diseases.
We do multidisciplinary research: #StructuralBiology #Biochemistry, #Biophysics and a bit of #CellBiology