#TFEB and #TFE3 control #glucose #homeostasis by regulating #insulin gene expression
Andrea Ballabio, Gennaro Napolitano and colleagues Tigem/Telethon
https://www.embopress.org/doi/full/10.15252/embj.2023113928

Interesting 🤔. A common mechanism, located at the lysosome, linking amino acid and energy stress to organelle biosynthesis.

A few of my favourites in this one: #FNIP1 #AMPK #TFEB #mitochondria #mTORc1

https://doi.org/10.1126/science.abj5559

TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers

Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn