Why is functional #autophagy important for #cardiac health?
Abel Lab and collaborators shows that #autophagic flux controls NAD+ homeostasis in #cardiomyocytes, thereby preventing #mitochondrial dysfunction
https://www.embopress.org/doi/full/10.1038/s44318-023-00009-w

Researchers reveal crucial role of #RNA in modulating #autophagic degradation of #protein condensates.

#PGL #SEPA #eIF4E

https://phys.org/news/2023-04-reveal-crucial-role-rna-modulating.html

TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers

Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241

A #protelysis cascade fine-tunes homologous #recombination repair in plants:
Arp Schnittger and coworkers show #KNOTEN1, stabilized by #UBP12/13, triggering K63-linked #ubiquitination and #autophagic degradation of #BLM complex subunit #RMI1 upon #DNAdamage

https://www.embopress.org/doi/10.15252/embj.2022111980