Lmst
Login

#TRPM8

RhyothemisRhyothemis@zeroes.ca
2024-02-02

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (2017)

ncbi.nlm.nih.gov/pmc/articles/

#TRPchannels #TRPM8 #Pain #Migraine #ChronicPain #nocicieption

The EMBO Journalembojournal@sciencemastodon.com
2022-12-21

Moderate cold is sensed by #TRPM8 channels, but what about extreme cold?
Peter McNaughton, Tamara Buijs et al at Kings College London identify a #STIM1-#ORAI-mediated mechanism in sympathetic #neurons that may prevent #frostbite through cold‐induced#vasodilation
embopress.org/doi/10.15252/emb

Schematic visualization of the article's synopsis: Extreme cold is not sensed via TRPM8 ion channels but by unclear alternative mechanisms. Here, we show that extreme cold causes STIM1-mediated aggregation and activation of ORAI calcium channels in somatosensory and sympathetic neurons.

Client Info

Server: https://mastodon.social
Version: 2025.07
Repository: https://github.com/cyevgeniy/lmst