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#TransTango

Albert Cardonaalbertcardona@mathstodon.xyz
2023-10-16

@biorxiv_neursci

"Metabolic constraints on growth explain how developmental temperature scales synaptic connectivity relevant for behaviour" by Züfle et al. 2023 biorxiv.org/content/10.1101/20

Uses #TransTango to study synaptic connectivity in the #Drosophila antennal lobe, and finds that:

"synaptic scaling leads to heterogeneous functional effects in different olfactory subcircuits, with striking consequences for odor-driven behaviors."

#neuroscience

Figure 2. Differen9al effects of temperature on wiring and wiring variability. A-C) TransTango analysis of connectivity of three different ORNs. Number of synaptic partners in different cell clusters of the AL, showing a differential increase across glomeruli. Boxplots indicate median and quartiles, whiskers indicate maximum and minimum values. Sample size at 18/25 oC: DM1 n=20/23, DL5 n=10/10, DL1 n=10/10, Kruskal-Wallis test *p<0.05, **p<10-2, ***p<10-3, *****p<10-5 D) Fold change in number of synaptic partners relative to 25oC. E) Allocation of ORN output synapses onto individual synaptic partners for the three glomeruli, as quantified from EM data (Hemibrain). The number of synapses was normalized to the total for each ORN class. Postsynaptic neurons are sorted based on the number of synaptic inputs they receive. Top: spatial location of the synapses analyzed (only right hemisphere). F) Percentage of postsynaptic neurons annotated in the Hemibrain dataset as mPNs and LNs.
Ko-Fan Chen 陳克帆kofanchen@drosophila.social
2022-12-20

@brembs very intrigued by how can motor neurons and vision info communicate in this operant self learning! Wondering if #TransTango or #Flywire would shed some light?

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