Isolation of a novel #human #prion #strain from a PRNP codon 129 heterozygous #vCJD #patient, https://etidiohnew.blogspot.com/2025/02/isolation-of-novel-human-prion-strain.html

Tory government 1990s : eating beef is safe. People died from #vCJD #MadCowDisease Tory government 2019: we will prosper after brexit. Science and facts > hope and spin #bbcbreakfast @BBCBreakfast

In case you haven't seen this interesting report:

"Two Hunters from the Same Lodge Afflicted with Sporadic CJD: Is Chronic Wasting Disease to Blame? (P7-13.002)"

https://www.neurology.org/doi/10.1212/WNL.0000000000204407

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Clusters of sporadic CJD cases may occur in regions with CWD-confirmed deer populations, hinting at potential cross-species prion transmission. Surveillance and further research are essential to better understand this possible association.
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For context, here's a fun article:

"Deer Are Beta-Testing a Nightmare Disease"
https://archive.is/ryj69

Yes, the prions can get on and into plants and remain a problem, but it's not clear if the prions can get into flowers, pollen, fruits, roots, tubers. I'm not that worried, yet. https://www.cell.com/iscience/fulltext/S2589-0042(23)02505-1

#CWD #vCJD #deer #hunting #hunters #meat #prion #prions

2/3

So when do we expect hunters to start dying from prion diseases? I don't think we'll know. It's going to be a surprise. With all the things tied to dementia now, it may just be one part of a complex causal pathway, a comorbidity.

Here's a nice microbiology podcast that goes a bit into prions: https://www.microbe.tv/twiv/twiv-878/

Here's a paper that shows that CWD can get into humans: https://link.springer.com/article/10.1007/s00401-022-02482-9 (unfortunately, tested on mice)

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Notably, our data suggest a different clinical presentation, prion signature, and tissue tropism, which causes challenges for detection by current diagnostic assays. Furthermore, the presence of infectious prions in feces is concerning because if this occurs in humans, it is a source for human-to-human transmission. These findings have strong implications for public health and CWD management.
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Here's another study: https://wwwnc.cdc.gov/eid/article/24/8/16-1888_article

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elk CWD prions could convert human PrPC from human brain and could also convert recombinant human PrPC expressed in transgenic mice and eukaryotic cell cultures
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#vCJD #CWD

Lucy Proctor investigates and presents the details of the devastating outbreak of BSE (Mad Cow Disease) and later vCJD in humans in the 80's/90s after the Animal Feed Industry formulated cattle feed that included rendered animal products inc. eyes and spines. Cows are vegetable eating ruminants.

https://www.bbc.co.uk/sounds/play/m001rrhx

https://en.wikipedia.org/wiki/Bovine_spongiform_encephalopathy

https://en.wikipedia.org/wiki/Meat_and_bone_meal

#audio #bse #vcjd #journalism #cattle #vegetarian