The 4th edition of the Integrative Structural Biology Meeting (#BSI), co-organized with the Association Française de Cristallographie (#AFC) and the Société Française de Biophysique (#SFB) will be held in Bordeaux 15th-19th of December 2025. Scientific sessions will cover a wide range of scientific research in the fields of #StructuralBiology , #Biophysics and #StructuralBiochemistry.
More information ➡️ https://bsi4.org/
@cnrs @afmblab.bsky.social @strucbio @ActaCrystF

Four cyanobacterial glycosyl transferase family 35 α-glucan phosphorylases of types I and II were biochemically characterized and one was crystallized and crystallographically analyzed #Cyanobacteria #CyanobacterialStarch #Glycogen https://doi.org/10.1107/S2053230X25007770

The higher resolution, significantly improved apo crystal structure of mouse gasdermin D will be beneficial for structure-based drug-design approaches towards this important pharmacological target #Pyroptosis #Inflammation https://t.co/h2dHmhraZQ

The SAMPREP workshop at the 2023 ACA Annual Meeting in Baltimore was designed to address the need to consoiidate cross-disciplinary best practices for sample preparation into a single forum @Penn #SamplePreparation #StructuralBiology #CryoEM https://doi.org/10.1107/S2053230X25007976

Take a look at our October issue: https://journals.iucr.org/f/issues/2025/10/00/

The cover shows the crystal structure of Cryptococcus humicola D-aspartate oxidase, which has a unique homotetrameric architecture in contrast to other known D-amino-acid oxidases. Read more at https://doi.org/10.1107/S2053230X25008192

The structure of a 7-substitution mutant of hydroxynitrile lyase shows that targeted amino-acid substitutions can shift catalytic geometries towards those of evolutionarily related enzymes #EngineeredProteins #HydroxynitrileLyases #HydrolaseFold https://doi.org/10.1107/S2053230X25007034

The World Directory of Crystallographers (WDC) offers an unparalleled compilation of expertise in the field.
It’s free to join and open to all crystallographers and other scientists employing crystallographic methods.
Add your name and be part of the mosaic:
🔗 www.iucr.org/people/wdc

Crystal structures of a clinically used histone deacetylase inhibitor, vorinostat, bound to the previously unidentified off-target proteins carbonic anhydrases II and IX are reported #HDACInhibitors #SAHA #Vorinostat https://doi.org/10.1107/S2053230X25007447

The crystal structure of Fasciola hepatica TPI has been solved at 1.51 Å and used to perform molecular-docking studies with the most successful fasciolocide triclabendazole #FasciolaHepatica #TriosephosphateIsomerase #TPI https://doi.org/10.1107/S2053230X25006454

Virulence protein J domain 1 maintains the canonical α/β-hydrolase fold but is likely to lack a functional catalytic triad, suggesting functional divergence from classical hydrolases of this superfamily #BacterialPathogens #TypeIVSecretionSystem https://doi.org/10.1107/S2053230X25006697

The first high-resolution structure of the folded domains of Xrs2 from S. cerevisiae will advance understanding of its functions in the DNA damage response and telomere-length maintenance #Nbs1Xrs2 #DNADoubleStrandBreaks #DNADamageRepair https://doi.org/10.1107/S2053230X25006867

Our September issue is available! https://tinyurl.com/58x22mpx

The cover shows the crystal structure of the N-terminal domain 1 of virulence protein J from Brucella abortus, which adopts an α/β-hydrolase fold but lacks the characteristic catalytic triad: see https://tinyurl.com/bdduy23d

A Cys64Ser mutant of the HRP-2 PWWP domain had an increased crystallization propensity, producing eight crystal forms that were pivotal to the execution of a crystallographic fragment-screening campaign #PWWPDomain #CrystalLattice #CrystalForms https://doi.org/10.1107/S2053230X25006302

Two structures of MenD from the Gram-positive pathogen Listeria monocytogenes are reported, as well as their oligomeric states in solution and functional characterization #ListeriaMonocytogenes #MenaquinoneBiosynthesis #SEPHCHCSynthaseMenD https://doi.org/10.1107/S2053230X25006181

Nucleotide-bound crystal structures of SARS-CoV-2 NSP13 in ADP- and ATP-bound states revealed that crystal packing influences NSP13 by stabilizing the nucleotide-binding site
#SARSCoV2 #NSP13Helicase #NucleotideBindingSite https://doi.org/10.1107/S2053230X25005266

Structural characterization of E. coli glucokinase suggests that phosphate could influence its activity by altering glucose binding and modulating interactions with a loop-interacting regulatory protein #Glucokinases #Hexokinases #PhosphateBinding https://doi.org/10.1107/S2053230X25005515

August issue now available: https://journals.iucr.org/f/issues/2025/08/00/

On the cover: one of 8 crystal forms of the Cys64Ser mutant of the hepatoma-derived growth factor-related protein 2 PWWP domain, which revealed a substantially improved crystallization propensity: https://doi.org/10.1107/S2053230X25006302

The first fully resolved crystal structure of human fascin1 is presented, fully modeling both molecules in the asymmetric unit and offering new insights into its conformational dynamics and structural plasticity #Cancer #Metastasis https://doi.org/10.1107/S2053230X25005254

Four structures of rsCherry exhibiting varying degrees of degradation indicate that oxygen-induced degradation of rsCherry predominantly affects the chromophore without altering the protein backbone #FluorescentProteins #CrystalStructure #Degradation https://doi.org/10.1107/S2053230X25005485

The structure of an apo unmutated sucrose phosphorylase from Alteromonas mediterranea shows the presence of two major catalytic conformations in the same crystal @DTUtweet @univnantes @ActaCrystF @IUCr #SucrosePhosphorylase #GH13 #Marine https://doi.org/10.1107/S2053230X25004327