That's it. I'm going back to Emacs.

Threat Actors Expand Abuse of Microsoft Visual Studio Code https://www.jamf.com/blog/threat-actors-expand-abuse-of-visual-studio-code/

Today's threads (a thread)

Inside: Google's AI pricing plan; and more!

Archived at: https://pluralistic.net/2026/01/21/cod-marxism/

#Pluralistic

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They say AI isn’t profitable. That’s not true.
Twice just this past week, I’ve been contacted and paid to fix problems caused by developers who relied on AI to configure servers.

#AI #IT #SysAdmin

I know the answer: for all of their talk about wizards create artificial general intelligence, compsci departments are actually now cranking out nothing but bot-writing dummies.

I was once again amazed by the utter brainlessness of the dweebs attempting to jack information out of my web sites. Where do they find such a wide variety of idiots?

PFKBK2:p―6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2―is 1 of 4 tissue specific genes that form homodimers that have both an nward kinase domain & a cward phosphatase domain. For this paralog when the pS acceptors are are occupied, the phosphatase is inactivated & kinase enhanced.

https://paulwells.substack.com/p/the-carney-doctrine

The coronal mass ejection that hit the earth's magnetic field yesterday has stirred up a severe geomagnetic storm (G4) & lit up the #aurora over night.

AKAP12:p pretty much begs me to ask the question: «If ubiquitination tags are meant to indicate misfolding, what is the reason that there are so many occupied acceptors in a protein bereft of folding?» #proteomics

Texting with a friend in the Twin Cities and they just went "Have to go, I hear helicopters," which reminds me that now is an excellent time to say fuck ICE and fuck this fascist administration

Winter makes a comeback across the Western Plains.

A triad of pS acceptors in a dynamic region that all evidence suggests are occupied simultaneously in both human (shown) & mouse AKAP8:p. Doesn't look like PKA is the offending kinase, though.

I think #Windows is even worse than we suggest. I had a bunch of "bricked" laptops that I've now improved with #Ubuntu and they all run great. Why did we ever put up with that ridiculous, circling ring? Why was it ever okay to stop whatever process and begin an update? I wonder if there are other terrible products that we've accepted simply because they're ubiquitous.

#Linux

You probably already know this, but the relative positions of the coiled-coils in this structure are meaningless: they are a consequence of the AF algorithm's bias towards the sort of old-fashioned "globular" structures that most chaperonins consider to be quite déclassé.

Occupied pS acceptors adjacent to helices (green) tend to occur in simpler patterns (onesie/twosie) than those in free-range dynamic regions, which often occur in clusters. You can see the coiled-coils adjacent to the green acceptors in the AF structure. #proteomics_101

https://www.cbc.ca/news/politics/trump-cryptocurrency-investment-9.7047169

Even when the opportunity poses itself, protein kinases tend to steer clear of the dynamic regions adjacent to β strands. #proteomics_101

Human SPECC1L:p―sperm antigen with calponin homology and coiled-coil domains 1 like― in addition to having a terrible name, has 3 occupied pS acceptors (green lines) snuggled up against the end of helical domains. Two of them are just cward of helices & one is just nward. #proteomics_101