Ferrari et al. find that while parameter scaling improves efficiency, strong scaling distorts diversity, intensifies background selection, and alters linkage patterns.

🔗 doi.org/10.1093/gbe/evaf097

#genome #evolution #bioinformatics

///Lifemap///
Produced by the CNRS, this site interactively explores the evolutionary relationships between all known species.
https://lifemap.cnrs.fr/
More resources at www.libresites.org
#interactive #relations #evolution #CNRS #living #species #lifemap

Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes https://www.biorxiv.org/content/10.1101/2025.05.28.656604v1?med=mas

Minimal overlaps in responses to insecticides between pollinator species https://www.biorxiv.org/content/10.1101/2025.05.19.654787v1?med=mas

Tspecies, Rapid Optimization for Estimating Species Divergence Time Using Ks Distribution https://www.biorxiv.org/content/10.1101/2025.05.18.654758v1?med=mas

This is going into my undergrad teaching as "yes natural selection still affects humans"
https://www.nature.com/articles/s41586-025-09031-w

Efficient Estimation of Nucleotide Diversity and Divergence using Depth Information https://www.biorxiv.org/content/10.1101/2025.05.15.654353v1?med=mas

The landscape of fitness effects of putatively functional noncoding mutations in humans https://www.biorxiv.org/content/10.1101/2025.05.14.654124v1?med=mas

Remembering January's editorial from our EiC's Brandon Gaut and Claudia Russo:

"The question for you, as an author, is where to spend research funds. Is it better to publish in journals that profit your academic community or profit from that community?"

🔗 doi.org/10.1093/molbev/msaf022

The distribution of fitness effects varies phylogenetically across animals https://www.biorxiv.org/content/10.1101/2025.05.13.653358v1?med=mas

Phyloformer by Nesterenko et al. is a deep learning method for phylogenetic inference that estimates evolutionary trees directly from sequence alignments, often outperforming traditional methods in speed and accuracy.

@laurentjacob.bsky.social

🔗 https://doi.org/10.1093/molbev/msaf051

#evobio #phylogenetics

"Despite Biotech Efforts to Revive Species, Extinction Is Still Forever"
https://e360.yale.edu/features/de-extinction

Even if one can create a genome that is identical to and individual representative of the original species (very unlikely), a species is more than just a bunch of genetically identical individuals (clones). A species capable of adapting requires genetic diversity--a population of genetically unique individuals.

#extinction #biodiversity #ecology #evolution

Empirical validation of the nearly neutral theory at divergence and population genomic scale using 150 mammals genomes https://www.biorxiv.org/content/10.1101/2025.04.17.649326v1?med=mas

New paper by Lewin & Eyre-Walker finds a strong negative correlation between generation time and yearly mutation rate. This highlights generation time as a key driver of molecular evolution across eukaryote clades.

🔗 https://doi.org/10.1093/molbev/msaf069

#NewPaperAlert #LanguageEvolution

Stupéfiant : le climat de la planète déraille, sous nos yeux, mais nous regardons les soubresauts spéculatifs des marchés financiers.
L'année 2024 est la plus chaude jamais enregistrée en Europe
On devrait immédiatement lancer des plans d'urgence ... mais non, tout le contraire.

Aevol-9: A simulation platform to decipher the evolution of genome architecture https://www.biorxiv.org/content/10.1101/2025.04.10.648095v1?med=mas

Public service announcement: this is *not* a dire wolf.

It is a genetically modified grey wolf made to resemble an extinct species, so a bullshit company can raise more money for their bullshit projects.

#Deextinction is a scam on so many levels I don't even know where to begin. It will *not* help us save endangered species. Instead, we should spend our money on preserving their habitats *before* they go extinct.

#Deextinction is a BS scam and a distraction from real conservation work. It's the AI of biology. They are genetically modifying animals to superficially resemble extinct species while vaguely gesturing towards sci-fi ideas about finding/reconstructing entire genomes. We are nowhere near this stage, and it's doubtful we ever will. And guess what, that still wouldn't bring anything back, because living things are much more than their DNA on so many levels.

La vie c'est l'évolution: mutation, hasard et sélection naturelle suffisent à expliquer la diversité du vivant que nous observons aujourd'hui. Mais comment a pu émerger ce processus d'évolution? Pour creuser cette question, je recommande chaudement ce livre passionnant que Sylvain Charlat vient de publier: "L’évolution sans-gêne – Aux origines de nos origines <https://www.seuil.com/ouvrage/l-evolution-sans-gene-sylvain-charlat/9782021573299>".
(an English version is in preparation)

Le documentaire diffusé ce soir sur France5 est retors : il ripoline les profils de complotistes pour les intégrer à un narratif qui semblé policé, mais est très orienté. Et, comme le font les complotistes, il accumule les éléments dans un sens sans se soucier de leur cohérence. ▫️1/10