We reconstructed the recent transmission history of #YellowFeverVirus in #Brazil. A suitability index was able to capture the seasonality of #zoonotic cases. Spatial modeling revealed hotspots with both past reporting and low #vaccination coverage, coinciding with the largest urban centers in the Southeast. #Phylodynamics identified 3 lineages & provided proof of the directionality of a spatial corridor connecting the endemic North with the extra-Amazonian basin.
José Lourenço
Ecologist of infectious diseases.
Spaceships & pathogens.
🇵🇹🇬🇧🇪🇺🌈🎮
Católica Biomedical Research Center
Will #ClimateChange amplify #epidemics and give rise to #pandemics?
(our new manuscript) Uruguay experienced its first Chikungunya virus outbreak in 2023, resulting in a significant burden to its healthcare system. We conducted analysis based on real-time genomic surveillance (30 novel whole genomes) to offer timely insights into recent local transmission dynamics and eco-epidemiological factors behind its emergence and spread in the country.
During the ZIKV public health crisis (2015-2018) Brazil reported low circulation of DENV. In 2018 DENV resurged with large outbreaks. DENV incidence after 2018 reveals a decrease in mean age of infection in regions most exposed to ZIKV. Using modelling we show that a combination of a short-term protection period to DENV followed by DENV disease enhancement in those exposed to ZIKV can reconcile the observed post-ZIKV DENV epidemiology.
https://www.medrxiv.org/content/10.1101/2023.05.29.23290597v1
#OneHealth #YellowFever #Brazil, soon in Science Advances.
2015-2022 phylodynamics provided proof of directionality connecting the endemic Amazon to the South East. We identify municipalities with high likelihood of spillover & low vaccination, that border urban centres & should be targeted for catch-up #vaccination.
Collaborative work with a large number of local & international researchers, epidemiologists, public health policy makers, ecologists & zoologists.
https://www.medrxiv.org/content/10.1101/2023.01.13.23284525v1
We mapped the global climate-driven transmission potential of #dengue by Aedes #aegypti (1981-2019) & offer a database & R-package as resources towards the identification of past and recent transmission hotspots.
This was hard work by Taishi Nakase, a student from the MSc programme Modelling for Global Health, from NDMOxford@twitter UniofOxford@twitter. Thanks also to the support of Mittenavoig@twitter & UriObolski@twitter climade_health@twitter
The study "The impacts of #SARSCoV2 vaccine dose separation & targeting on the COVID-19 epidemic" in Nature showing how targeting disease (not transmission) by focusing on the vulnerable was the right choice in the UK (and should have been universally).
Through a combination of phy and epi models we reconstructed the recent transmission of #yellowfever virus in #Brazil.
#Modelling revealed spatial hotspots with both past reporting and low vaccination coverage, which coincided with the largest Southeast urban centres.
#Phylodynamics unravelled three distinct #YFV lineages, and provided proof of the directionality of a known spatial corridor of spread that connects the endemic North with the extra-Amazonian basin.
https://www.medrxiv.org/content/10.1101/2023.01.13.23284525v1
Have a look at our newest initiative (this is work in progress, but we are activily updating the website):
Climate Amplified Diseases and Epidemics (CLIMADE): A global consortium led by the global south to study and respond to Climate Amplified Diseases and Epidemics
The overarching long-term goal of CLIMADE is to predict, track and control diseases and epidemics that are amplified by human-caused climate change in the most affected countries in the world.
We (*) decided to face the Biggest Global Problems: Climate Change & Epidemics - Together with some of the top funders in the world, we are looking for the best minds to take Fellowships in #Epidemiology, #Ecology and #Climate Studies
(*) Big initiative led by Tulio de Oliveira: https://twitter.com/Tuliodna
More info here:
https://krisp.org.za/news.php?id=610
https://www.krisp.org.za/manuscripts/PostDoctEcoClinmate2023.pdf
We have been working with Yellow Fever virus genomics and epidemiological data, and will soon preprint our study entitled: “Genomic #epidemiology unveils a novel corridor of #YFV spread that fuelled the ongoing southern #Brazilian epidemic". We identify spatial hotspots of spillover events and in need of higher vaccination coverage, and also describe the 2015-2022 spatial spread of 3 YFV clades. Stay tunned.
We are looking for #mosquito data on natural oscillations in mosquito population size (any life stage). We like #aedes #aegypti and #culex #pipiens !
We are working on quantifying #ecological drivers of #yellowfever in the South and Southeast of #Brazil. Curious to see what the hashtag gives, so using this as a test 🤔
Looking to work on eco-epi #modelling in #Brazil 🇧🇷 ? Lacking some critical #data? Have a look at this great dataset from Abdalla and colleagues "Statistically enriched #geospatial datasets of Brazilian municipalities for data-driven modeling".🔬
Over the last three decades, the global distribution of #dengue has rapidly expanded, causing detrimental #health and economic problems in many areas of the world. We mapped the global climate-driven #transmission potential of dengue virus transmitted by Aedes #aegypti #mosquitoes from 1981 to 2019. This #database and an R package are offered to the public health community as resources towards the identification of past, current and future transmission hotspots.
https://www.medrxiv.org/content/10.1101/2022.11.04.22281958v1
Hey there! I am an #academic in the area of animal #infectious #disease. I work mainly with mosquito-borne viruses and multi-strain #pathogens. Currently I am a PI at BioISI/FCUL of the University of Lisbon. New to this platform. Am on Twitter as well @lourencoJML #introduction
I am going to repost the few toots I already had because I have now moved to a more suitable instance 👍
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