Mascot Newsletter, January 2026:
Ion intensity: peak area vs signal to noise?
Duplexing deuterated water-labeled samples for protein turnover rate estimation.
Role-based access with Mascot Security is useful in a variety of cases.
#MassSpec
Maximize your ESI sensitivity with CoAnn’s pulled and sharpened emitters.
The different emitter types offer flexibility to match various nanoLC columns and liquid infusion measurements in varieties of #MassSpec applications.
Learn more: https://www.mswil.com/nano-cap-micro-lc/spray-emitters/pulled-emitters/coann-pulled-emitters/
🚀 EuBIC-MS Winter School 2026 in Harrachov!
Join us for an intro to computational MS & a hands-on pyOpenMS session
🎯 Learn workflow building blocks, explore MS data, and start scripting with open-source tools.
📅 Jan 19
🔗 More information: https://www.denbi.de/training-courses-2026/2008-pyopenms-for-metabolomics
#MassSpec #Proteomics #EuBIC2026
Proteomics software is prone to filling up the disk with data and temp files, which can cause weird issues. This blog article lists the most common errors in Mascot products and how to free up disk space.
https://www.matrixscience.com/blog/strange-software-failures-check-your-disk-space.html
🎁 Season’s Greetings & Gratitude
Thanks for choosing us in 2025.
Wishing you a peaceful holiday season and a successful new year — from our team to yours!
#mswil #proteomics #LCMS #MassSpec #MassSpectrometry
#Proteomics #Chemistry #BioMedical #Pharmancy #Metabolomics #Physics #MSWil #MakingScienceWork
Mascot Newsletter, December 2025:
NCBI nr FASTA replacement.
Immunoregulation during pregnancy.
Mascot Server as system service on Linux.
After a fair bit of frustration, our new excimer laser is installed! We have it coupled to an Element 2, and new laser plus sector magnet (rather than quadupole) mass spectrometry is a steep learning curve for me. Nice to spend the afternoon tinkering in the lab though.
When raw data is processed into peak lists, there is a choice: how should peak intensity be calculated? Mascot Distiller defaults to peak area. The alternative, signal-to-noise (S/N), can be useful with detecting diagnostic ions.
https://www.matrixscience.com/blog/peak-list-arcana-area-vs-signal-to-noise.html
Mascot Newsletter, November 2025:
Top-3 quant with DDA-PASEF.
ZooMS peptide markers for South American Xenarthrans.
Migrating from Windows 10 to Linux could extend the lifetime of your hardware.
The NCBI nr FASTA file of protein sequences is no longer updated. We've summarised instructions for creating it from the BLAST database -- or you may be better off using TrEMBL.
https://www.matrixscience.com/blog/replacements-for-ncbi-nr.html
Mascot Newsletter, October 2025:
Spectrum-centric DIA scoring.
Molecular mechanisms of SBK2 kinase on the heart.
Windows update issue with IIS (resolved).
Der Mann hat was neues für #Lupus gefunden - oder wie @kabalak selbst sagen würde:
In conclusion, this study uncovers a new dimension of immune crosstalk: a proteolytic plasma network that generates immunoactive fragments with intrinsic self-regulatory capabilities to modulate #inflammation and tissue injury in complex disease contexts. Deciphering these immunoactivities may pave the way for innovative diagnostic and therapeutic strategies in complement-driven pathologies, potentially benefiting a wide range of inflammatory and autoimmune diseases.
#AutoimmuneDiseases #InflammatoryDisease #Science #SLE #proteomics #MassSpec #TeamMassSpec #LupusResearch
https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8
Next @denbi.bsky.social #training course: 🔬🚀 OpenMS Training & Open House 2025 in Toronto!
📅 Nov 9 | 10AM–2PM | 🏛️ U of Toronto
Hands-on sessions in #proteomics & #metabolomics: OpenMS, pyOpenMS, WebApps, DIA, data viz & more.
🤝 https://www.denbi.de/training-courses-2025/1965-openms-training-open-house-2025
#OpenMS #MassSpec #Bioinformatics
🚀 Registration is open for EuBIC-MS Winter School 2026! ❄️🧬
📍 Harrachov, Czechia
🎙️ Keynotes | 🛠️ Workshops | 🤝 Networking
Supported by @deNBI. This event is a must for anyone in #Bioinformatics, #Proteomics, or #Metabolomics.
🔗 https://eubic-ms.org/events/2026-winter-school/
#EuBIC2026 #MassSpec @eubic-ms.org
Mascot Daemon can export protein level quant intensities for replicate LFQ, SILAC and iTRAQ/TMT. The latest version can also export intensity values calculated using the "Top-3" method, illustrated here with DDA-PASEF data.
I just submitted my manuscript for November's meeting of the NVMS!
#MassSpec #Proteomics #Bioinformatics
@magnuspalmblad
@Stephanhacker2
https://www.nvms.nl/
Still looking for the right equipment for your #MassSpec research? We offer a wide range of MS Consumables (e.g., spray emitters, nlc columns, ion sources), Services (e.g.,filament repair) & Software Solutions (e.g., NIST, Wiley, SIMION, etc.).
✨Visit: https://www.mswil.com/
We are pleased to announce a new distributor for Matrix Science products! Customers in India can now buy Mascot Server through BioInnovations, who provide instruments, software, services and consumables for life sciences and analytical and clinical labs. #proteomics #massspec
https://www.matrixscience.com/whats_new/new-mascot-distributor-in-india-bioinnovations.html
Probabilistic scoring of DIA matches without spectral deconvolution? Not only is it possible, we're working on implementing it in Mascot DIA.
https://www.matrixscience.com/blog/probabilistic-spectrum-centric-scoring-for-dia.html
I'm currently writing a paper in with positron and quarto. Managing to go from raw #massspec #proteomics data to papers in pdf for pre-print and docx for coauthors to easily coment and revise. It's pretty cool.
RE: https://bsky.app/profile/did:plc:5ol3bgc5trbdgd5h34wynrwo/post/3lwtpvqdu622c
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Server: https://mastodon.social
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