Surgical Referral in LMICs Review:

📊 14 studies analyzed.
🔍 Multiple shortages in surgical resources.
🔗 Lack of referral protocols.
🔄 Improves coordination could enhance pathways.

#LMICs #SurgeryEfficiency #Healthcare #Research #Pub2Post

https://tnyp.me/Tj77mO7J/m

Small intracellular vesicles outperform extracellular in uptake, drug delivery, and neuroprotection
🎯Intracellular vesicles yield smaller and higher quantities
⚙️Enriched with proteins linked to ER and Golgi
🔬 Higher drug-loading efficiency
#Neuroprotection #BiomedicalEngineering #VESisolation #MSC #DOI https://tnyp.me/vsUbO3zG/m #Pub2Post

Variations in U4 and U6 snRNA genes lead to retinitis pigmentosa.

🧬 153 RP cases found with RNU4-2 and RNU6 variants in 67 families
🧬 Variants located in U4/U6 duplex's vital junction
🧬 ~1.4% of undiagnosed RP cases explained by these variants
🧬 Potential impact on tri-snRNP splicing factors

#Genomics #Spliceosome #RetinitisPigmentosa #NoncodingRNA #Pub2Post

https://tnyp.me/JoO75rwP/m

CLAIM 2024 Update: Enhancing AI reporting in medical imaging
📈 Widely adopted with 883 citations
🧑‍🔬 Expert-panel Delphi methodology
📚 Streamlines AI reporting in medical imaging

#AI #MedicalImaging #CLAIM #Pub2Post https://tnyp.me/qI1nI0PN/m

"Re: Testosterone Therapy Guidelines"
📉Single biochemical thresholds oversimplify
🧠Tailoring cutoffs to specific endpoints is crucial
📈Symptoms should guide diagnosis #Hypogonadism #Endocrinology #Pub2Post https://tnyp.me/go6OJMXm/m

Loss-of-function mutations in PLD4 linked to SLE:

🔬 PLD4 mutations led to high TLR7/9 activation
🔬 5 patients showed reduced exonuclease activity
🔬 Effective baricitinib treatment in mice

#SLE #Genetics #Inflammation #Pub2Post
https://tnyp.me/vwTf6xf5/m

Small intracellular vesicles (sIVs):
🔬 Smaller size, higher yield
📊 5-10x protein vs. small extracellular vesicles (sEVs)
🚀 Enhanced drug delivery
#Neuroprotection #BiomedicalEngineering #Pub2Post https://tnyp.me/vsUbO3zG/m

Newly identified RNU4-2 and RNU6 variants link to retinitis pigmentosa.

📊 Includes 153 affected individuals, 67 families.

🌍 RP affects ~2 million globally.

#Genetics #RetinitisPigmentosa #RNA #Pub2Post https://tnyp.me/JoO75rwP/m

3D-printed models improve RCC with VTE surgical planning

🩺 Fewer ICU stays (52% 3D vs. 48% image)
🛡️ Lower severe complications (OR: 20.46 attested)

#3DPrinting #RCC #ClinicalTrial #Urology #MedicalInnovation #Pub2Post

https://tnyp.me/5PtUuN7c/m

Glycan Shielding Enables TCR-Sufficient Allogeneic CAR-T Therapy
🔬 SPPL3 deletion enhances T cell glycosylation patterns

#CAR-T #B-NHL #CancerTherapy #Pub2Post
https://tnyp.me/FbhvQ66a/m

Review of surgical referral systems in LMICs highlights:

📊 Streamlined coordination improves system efficiency.

#HealthSystems #LMICs #Surgery #HealthcareReform #Pub2Post

https://tnyp.me/BQ4J2biE/m

✔️ WHO checklist usage higher in first referral (99.4%).
📉 No significant difference in 30-day mortality between hospitals.

#GlobalSurgery #HealthcareResearch #LMIC #Pub2Post
https://tnyp.me/k32Aqpbj/m

Aeromonas variant enhances ulcerative colitis risk.

📊 CCR2⁺HLA-DR⁺ macrophages ↑ in inflamed colon
📊 Th17 cells linked to inflammation
📊 Differences in immune cell frequencies

#UlcerativeColitis #Immunology #Pub2Post https://tnyp.me/gVgDODuX/m

Irregular Diet and Esophageal Cancer:

🍽️ 6 studies analyzed
📊 Found RR of 4.181 (95% CI 2.196 – 7.960)
🔬 Heterogeneity sources: non-disease, nurses, Asians

#EsophagealCancer #IrregularDiet #MetaAnalysis #Genetics #Pub2Post https://tnyp.me/gQApwmOQ/m

Myocardial infarction influences AAV-based gene transfer.
🧬 MI enhances cardiac AAV transduction, peaking on day 3 post-MI in mice
🔬 Excessive AAV enrichment independent of serotypes
#GeneTherapy #Cardiology #AAVResearch #Pub2Post https://tnyp.me/VJ61sNPM/m

Title: Enhancer Remodeling by OTX2 Directs Specification and Patterning of Mammalian Definitive Endoderm

🔍 OTX2 is critical for definitive endoderm patterning.

#OTX2 #DevelopmentalBiology #Endoderm #GeneRegulation #Pub2Post https://tnyp.me/s3IJY0xx/m

Mapping sensory circuits to bone uncovers signals for healing

🧠 Studied tdT+ DRG neurons over 1-4 weeks in mice (N=3)
🔬 N=1,020 neurons analyzed from N=12 DRGs

#Neuroscience #FractureHealing #Pub2Post
https://tnyp.me/cfIIn4pb/m

CLAIM 2024 Update:
🔍 275 PubMed, 608 Scholar citations
📈 New "Yes, No, NA" options
🔄 "Reference standard" over "ground truth"
#AI #MedicalImaging #CLAIM2024 #Pub2Post
https://tnyp.me/qI1nI0PN/m

2025 ATA Guidelines: Differentiated Thyroid Cancer

🧪 Revised regimen covers cancer diagnosis to subsequent therapies
📊 Data-driven decisions prioritize patient journey in DTC

#ThyroidCancer #DTC #ATAGuidelines #Pub2Post

https://tnyp.me/klrDiXX5/m

Histone variant H3.14 responds to abiotic stress in Arabidopsis:
🌱 H3.14 expressed in root transition zone
🔬 Dual role: activates stress genes, represses
More at https://tnyp.me/S0eSd1Ut/m
#Arabidopsis #StressResponse #Chromatin #H3Variant #Pub2Post