Lmst

#RNAmodifications

What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @PLOSBiology https://plos.io/3SUN4we

Left: Coronal brain sections of control (top), heterozygous (middle) and knockout (bottom) mice at E13.5 were stained with antibodies recognizing BrdU and Ki67. Pregnant mothers received a BrdU pulse 24 h before embryo collection. Representative cortical regions were shown. Scale bar, 50 μm. Right: A model in which the m5C reader protein Ybx1 regulates the stability of transcripts of key cell cycle regulatory proteins, and its loss leads to impaired proliferation and differentiation in cortical progenitor cells. Image credit: Jian Zhang

📚 Our latest review article "Beyond the Anticodon: tRNA Core Modifications and Their Impact on Structure, Translation, and Stress Adaptation" is out!
🎯 Read more about tRNA core modifications, which should not be overlooked in favor of their anticodon-loop counterparts. #tRNA #RNAmodifications #Translation #StressAdaptation

https://www.mdpi.com/2073-4425/15/3/374