Thinking of #music... @dariquima &co show that mental manipulation of a melody systematically changes its neural representation in #auditory, association, #sensorimotor & #subcortical areas, reflecting volitional control of auditory images #PLOSBiology https://plos.io/3NBg7lV

***New preprint alert***
"Pathway-specific progression of Tau pathology in the human thalamus"
We discovered that large presynaptic terminals containing vGLUT2 preferentially accumulate paired helical filaments of #Tau in the anterodorsal nucleus of the #thalamus, even at the stage before #Alzheimer’s disease.
But we could not detect them in the small corticothalamic terminals, suggesting Tau is not spreading anterogradely from the #cortex.
We also detected pathological Tau in both presynaptic and postsynaptic sites, which suggests Tau crosses specific #synapses.
Adjacent thalamic nuclei such as the anteroventral and mediodorsal were relatively resistant to Tau #pathology.
We suggest there is a 'hidden' #subcortical route for the spread of Tau in the ageing human #brain.
Since the anterodorsal thalamic nucleus is so vulnerable, and contains high densities of #neurons that are sensitive to head direction and gravity, it may explain the very early deficits in spatial orientation in people that go on to develop Alzheimer’s disease.
Please see our #preprint for further details:
https://www.biorxiv.org/content/10.1101/2023.06.05.543738v1

Higher-order sensory #ThalamicNuclei are densely connected with multiple #cortical & #subcortical areas, but what do they do? During active sensing, the POm integrates information from the #cortex & plays a key role in #SensoryPerception #PLOSBiology https://plos.io/3XFqbhx

Higher-order sensory #ThalamicNuclei are densely connected with multiple #cortical & #subcortical areas, but what do they do? During active sensing, the POm integrates information from the #cortex & plays a key role in #SensoryPerception #PLOSBiology https://plos.io/3XFqbhx

Higher-order sensory #ThalamicNuclei are densely connected with multiple #cortical & #subcortical areas, but what do they do? During active sensing, the POm integrates information from the #cortex & plays a key role in #SensoryPerception #PLOSBiology https://plos.io/3XFqbhx

Hello! Server change, so here's my re-introduction 👋

I'm a research scientist at the University of Pittsburgh studying #subcortical contributions to human #auditory processing and communication 🗣️ 👂 🧠

Really happy to see this place take off—excited to use it to keep building a fairer, more vibrant scientific community!

Overdue #introduction #1stToot

Hi 👋🏼! I’m a #neuroscience Instructor in Rudebeck’s lab at #MountSinai NY.

Strong focus on animal #learning #DecisionMaking #Reward #valuation and how #prefrontal #subcortical regions represent these and interact at the level of #neurons and #LFP.

Proponent of recording neurons in too many areas simultaneously, and a #Matlab enthusiast (I know.. I complain about it too!).

Off lab, you will find me #biking , pushing a #stroller , and/or enjoying #beers.