Why do studies claiming #Treg induction by novel designer drugs test them only when given before or with antigen, rather than in established disease that more closely reflects human cases?
#treg
This study of natural food-specific #Treg development, two years in the making, reveals surprising results that challenge using artificial antigens like OVA. “BioRxiv v2, posted recently, likely signals journal acceptance.
Recent Treg biotech trajectories show that current Treg-based tech do not work. Why? Unlike conventional T cells, Tregs operate within a tripartite system involving the microbiota and naturally IL-2–producing T cells.
Novel Approach To Transplant Immunosuppression directs the body’s immune system to censor itself permitting transplanted human organs to flourish without medicinal immunosuppression. #transplantation #immunosuppression #Treg #antibodies #presensitized
https://www.instagram.com/p/DN06krQ2q-f/
Regulatory #Tcells (Tregs) exist in distinct subsets, but how is this regulated? Saxena & He explore a recent @PLOSBiology study showing that the class III PI3K Vps34 acts as a master orchestrator, driving effector #Treg generation & maintenance. Paper: https://plos.io/42xmddU Primer: https://plos.io/4lz0hYA
Leggevo su un giornale generalista di una recentissima pubblicazione scientifica di una università in Svizzera riguardo ad un innovativo approccio nella ricerca di base per la cura della #celiachia (un'amica in classe di mia figlia è celiaca) con l'uso delle #Treg. Ovviamente il giornale si guarda bene da citare puntualmente dove sia tale pubblicazione come fonte, ma ok, con una rapida ricerca la trovo. Volevo leggermela più in dettaglio, ma è a pagamento
https://www.science.org/doi/abs/10.1126/scitranslmed.adr8941
Nasal Spray Blunts Traumatic Brain Injury: Harvard’s Brigham and Women’s Hospital has found that a nasal spray containing an anti-CD3 monoclonal antibody significantly reduces brain inflammation and speeds recovery. #traumaticbraininjury #tbi #cd3 #treg #il10 #mva #nasalspray
https://www.instagram.com/reel/DHD28nmuKit/
'We found that up-regulation of a primate-specific short isoform of PRDM1-S induces expression of SGK1 independent from the evolutionarily conserved long PRDM1, which led to destabilization of #FOXP3 & #Treg dysfunction. This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune diseases.'
#Immunology
https://www.science.org/doi/10.1126/scitranslmed.adp1720
"The Swiss drugmaker also defenestrated three phase 1 programs. Anti-CD25 Treg depleter RG6292 landed on the discard pile. Roche previously stopped a monotherapy clinical trial but continued to study RG6292 in combination with its checkpoint inhibitor Tecentriq."
#Immunology #Treg
https://www.fiercebiotech.com/biotech/roche-pumps-brakes-pompe-axing-gene-therapy-after-assessing-competition
'Bender et al. report that a phase 2 randomized trial of a single dose of expanded Tregs showed no efficacy in preserving C-peptide, an indicator of β cell function, in early-onset T1D. This negative in vivo result comes despite the suppressive capacity of the expanded Tregs in vitro, and will inform future studies of the role of polyclonal Tregs in T1D.'
#Immunology #Immunotherapy #Treg #Diabetes
https://www.science.org/doi/full/10.1126/scitranslmed.adn2404
'However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysis of the transcriptomes of murine Treg and conventional T cells (Tconv), we observe that the proenkephalin gene (Penk), encoding the precursor of analgesic opioid peptides, ranks among the top 25 genes most enriched in Treg cells.'
#Immunology #Preprint #Neuroimmunology #Treg
https://www.biorxiv.org/content/10.1101/2023.09.12.557326v2
Attorney General Treg Taylor Joins 26 States In Support Of Texas Border Defense
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Border Fence by Dan Heaton, U.S. Air Force (DOD Photo 061003-F-1726H-004)
(Anchorage, AK) – On Monday, Alaska Attorney General Treg Taylor joined 26 other states in an Iowa and Utah-led letter to the Biden Administration, supporting...
https://alaska-native-news.com/attorney-general-treg-taylor-joins-26-states-in-support-of-texas-border-defense/72393/
#texas #border #fence #treg #taylor #support
"Here, by comprehensively mapping 3D #chromatin organization during #Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additionally, the binding sites of #Foxp3, a Treg lineage specifying #transcription factor, were highly enriched at Treg-specific chromatin loop anchors."
Treg cells are a category of T cells whose properties make them a candidate for potential treatment therapies for #IBD. We eagerly await the outcome of clinical trials using this approach that are currently underway.
#crohns #crohnscolitis #crohnsandcolitis #inflammatoryboweldisease #treg #tcells #tcell
Outrage as Alaska Attorney General Asks Supreme Court to Reverse EPA's Pebble Mine Veto
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One coalition described the Republican attorney general's lawsuit as "little more than a publicity stunt filed on behalf of an unscrupulous mining company."
Treg Taylor. Image-Internet screengrab
The state of Alaska...
https://alaska-native-news.com/outrage-as-alaska-attorney-general-asks-supreme-court-to-reverse-epas-pebble-mine-veto/69117/
#treg #taylor #pebble #supremecourt #alaska
The work on the DC - quite descriptive - is published. Find it here: https://mastodon.social/@tinyspheresof/109681388538649498
The T cell work has not been published. I think I have a mostly complete manuscript that I could put on bioRXv. I'll discuss it with my former PI.
The short version: #IL6 and #TNF were very abundant, and were in the way of Treg-Teff interaction, #Teff not reacting to #Treg suppression anymore. Possibly partly explaining why drugs against these work in #arthritis.
Lilly walks away from Nektar's PEG conjugate of rhIL-2, rezpeg - aka rezpegaldesleukin, aka NKTR-358 - after disappointing phase II results in lupus.
#Immunology #immunotherapy #RegulatoryTCell #Lupus #Treg #drugdevelopment
@weldeiry Nice succinct overview of CD4+ #Tcells in #cancer #immunology. Also a short paragraph on cancer promotion by (a subset of) these cells, a.o. #Treg.
Thanks for sharing.
"Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo #FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas #th17
partially converted toward a regulatory phenotype in the injured myocardium."
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322183
Review at EJI
"Dysregulation or overproduction of IL-6 leads to autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA), in which Th17 cells are considered to be the primary cause of pathology. Given the critical role of IL-6 in altering the balance between Treg and Th17 cells, controlling IL-6 activities is potentially an effective approach in the treatment of various autoimmune and inflammatory diseases."
#Immunology #Treg #Th17 #Autoimmunity
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201040391
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