#Tcells

datum (n=1)datum@zeroes.ca
2025-06-12

Perforin is the substance T and NK cells use to drill into an infected cell and kill it. Selin and Gill’s studies suggest that ME/CFS and long-COVID patients’ T cells produce almost no perforin

healthrising.org/wp-content/up

[alt text: graphs of perforin in two classes of cell. The healthy controls are tall grey bars, compared to 1/10 to 1/3 as tall bars for Long COVID and ME/CFS groups.]

they also found

a huge increase in a distinct type of T-cell called double-positive T-cell (CD4+ CD8+) in people with ME/CFS and/or long COVID. Instead of being differentiated into the two usual major T-cell subsets CD4 (helper/regulatory) and CD8 (killer) T-cells, these hybrid T-cells look like both CD4 and CD8 T-cells at the same time.

Selin found that these cells increased 8-9 fold in ME/CFS and long-COVID patients.

which compensates in part for the lower perforin, but also led to

a “highly dysregulated” cytotoxic T-cell immune response [...] That suggested that the immune system was kind of flailing around, trying to come up with an answer.

from healthrising.org/blog/2025/05/

#COVID #COVID19 #MECFS #LongCOVID #CovidIsNotOver #TCells #NKCells #CD8 #CD4

N-gated Hacker Newsngate
2025-06-08

Oh look, scientists claim they can sneak into T cells to tackle latency—because if there's anything more efficient than human cells, it's that suggests you upgrade your browser. 🙄🖥️ Maybe next they'll solve world hunger with a new app that only works on Netscape. 🍽️✨
nature.com/articles/s41467-025

Geekoogeekoo
2025-04-18

What if your immune system had a second, secret step that made it smarter and stronger? It does—and scientists just found it.

geekoo.news/the-immune-systems

2025-04-16

Regulatory #Tcells (Tregs) exist in distinct subsets, but how is this regulated? Saxena & He explore a recent @PLOSBiology study showing that the class III PI3K Vps34 acts as a master orchestrator, driving effector #Treg generation & maintenance. Paper: plos.io/42xmddU Primer: plos.io/4lz0hYA

Vps34 plays a crucial role in the differentiation of conventional Tregs (cTregs) into transitional effector Tregs (eTregs; PD‐1+) and subsequently into terminal effector Tregs (KLRG1+, ST2+) during perinatal development and their maintenance and function through post-perinatal life. Vps34, through AP‐1 transcription factors (TFs; Jun, Fos, BATF), facilitates transcriptional and epigenetic reprogramming essential for immune tolerance, thereby averting autoimmunity during perinatal life. Post-perinatally, the Vps34–Atg14 complex promotes autophagy, stabilizes mitochondria (reducing reactive oxygen species and regulating the Bim/Mcl-1 ratio), and sustains eTreg homeostasis (e.g., IL-7Rα/CD127 expression). Modulating Vps34 complex pathways—either by activation or inhibition—holds potential for clinical applications in treating autoimmune diseases and cancer. The authors acknowledge Biorender for figure generation.
Geekoogeekoo
2025-04-08

Even mild infections trigger the body's defense mechanisms for severe diseases. Discover how our immune system stays one step ahead.

geekoo.news/early-immune-respo

Technische Universität Münchentu_muenchen@wisskomm.social
2025-04-07

Dietmar Zehn, Professor of Animal Physiology and #Immunology, and his team showed that the body prepares itself for a severe course of illness even in the case of uncomplicated #infections by producing special #Tcells: go.tum.de/664167

@HelmholtzMunich

📷A.Eckert

2025-04-03

Immunotherapy of Camcer #ITOC11 conference started with a packed program and auditorium. Plenty of topics from immunobiology to clinical experimental immunotherapies. See www.itoc-conferences.eu
#immunotherapy #science #Immunology #medicine #TCells #tcellreceptors #cellulartherapies #macrophages #health

Auditorium view in MunichWelcome sign for ITOC conference
ZPONZzponz
2025-03-21

THE EXPERT EDGE BY ZPONZ:Expert in T Cells
Dr. Elias Sayour is the principal investigator of the RNA Engineering Laboratory within the Preston A. Wells, Jr. Center for Brain Tumor Therapy and UF Brain Tumor Immunotherapy Program. He is working to develop lipid-nanoparticles to train the immune system to fight cancer. Dr. Sayour's specialty is pediatric hematology-oncology.

N-gated Hacker Newsngate
2025-03-09

🎉 Groundbreaking news: , the hero of headaches, moonlights as a cancer-fighting ninja! 🥋Scientists discover it foils platelet TXA2's evil plot against T cells, while Nature.com battles browser compatibility issues like it's 2005. 🖥️
nature.com/articles/s41586-025

Howard Smith MD, AMDrhowardsmith@masto.nyc
2025-02-12

Ultrasonic vibrations, transmitted to killer T cells via micro bubbles, trigger a 3.6 fold greater release of tumor killing proteins from the T cells. #ultrasound #cancer #microbuttles #tcells #cytokines
instagram.com/p/DF_E2emOYkR/

Howard Smith MD, AMDrhowardsmith@masto.nyc
2024-11-18

Energize Cancer Killing T cells By Neutralizing Tumor Waste: An alternative immunotherapy strategy. #tcells #killercells #lacticacid #mct11 #transporter #cancer
instagram.com/p/DChra0zuq0F/

2024-11-01

Another great pre-print from the Killian Schober lab and accompanying tweetorial:
biorxiv.org/content/10.1101/20
x.com/kischober/status/1852222
It always feels like Xmas day when I see one of their publications. In this one, they followed the clonotypic and phenotypic dynamics of antigen-specific #Tcells from #SARS-CoV2 vaccinated individuals and found that peripheral clonotype expansion was more probabilistic than avidity driven. #immunology

Zoomers of the Sunshine Coast 🇨🇦SCZoomers@mstdn.ca
2024-10-19

Understanding Long COVID
Through CD8+ T Cell Responses

SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over two years
pnas.org/doi/10.1073/pnas.2411

See Also: Mast Cell Activation Episode
buzzsprout.com/2405788/episode

#CD8 #TCells #LongCovid #Vaccines #Study #TwoYears #Immunity ##Durability

buzzsprout.com/2405788/episode

2024-09-26

today I watched:

How Alzheimer's mutates the immune system | nature video

youtu.be/o_dbdhwNbig?si=P53kD4

5 min. interview with David Gate on CXCR3 expressing peripheral T cells and Alzheimer disease.

~

I wonder if thiamine deficiency increases CXCR3 expression?

#2dayIwatched #Alzheimers
#NeurodegenerativeDiseases
#Tcells #BrainHealth #immunology #neuroscience

Matt Willemsenmattotcha
2024-08-31
2024-08-23

Know your neighbours…🏘️

Spatial positioning determines tissue-resident memory T cell fate in the gut.

Marina Schernthanner covers work from Miguel Reina-Campos & colleagues. #preprint

#preLight ⬇️ 👀

prelights.biologists.com/highl

#biology #immunology #intestine #TCells #bioinformatics #transcriptomics

2024-08-15

Quality & longevity of CD4+ #Tcells change with age in mice. @AYatesGroup &co show that these cells have longer lifespans and become more quiescent when the organism ages, but these properties depend on cellular age, not on host age #PLOSBiology plos.io/46PBjgX

SIB Swiss BioinformaticsSIB@mstdn.science
2024-06-18

“This study represents a significant scientific breakthrough, as it shifts the paradigm in the understanding of MHC Class II peptides and their recognition by CD4+ T cells.”

🥁 One of the #SIBRemarkableOutputs 2023 👏

👉 More: tinyurl.com/3ah98n3j

#machinelearning #Tcells #CancerResearch

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