Researchers developed a new method to label and track #Tcells in the body using #PETimaging and engineered receptors. This could improve understanding of #celltherapy and support safer use in future treatments: http://go.tum.de/935833

#Immunotherapy

📷V. Morath

Perforin is the substance T and NK cells use to drill into an infected cell and kill it. Selin and Gill’s studies suggest that ME/CFS and long-COVID patients’ T cells produce almost no perforin

https://www.healthrising.org/wp-content/uploads/2025/05/Perforin_Selin_Webinar_25.gif

[alt text: graphs of perforin in two classes of cell. The healthy controls are tall grey bars, compared to 1/10 to 1/3 as tall bars for Long COVID and ME/CFS groups.]

they also found

a huge increase in a distinct type of T-cell called double-positive T-cell (CD4+ CD8+) in people with ME/CFS and/or long COVID. Instead of being differentiated into the two usual major T-cell subsets CD4 (helper/regulatory) and CD8 (killer) T-cells, these hybrid T-cells look like both CD4 and CD8 T-cells at the same time.

Selin found that these cells increased 8-9 fold in ME/CFS and long-COVID patients.

which compensates in part for the lower perforin, but also led to

a “highly dysregulated” cytotoxic T-cell immune response [...] That suggested that the immune system was kind of flailing around, trying to come up with an answer.

from https://www.healthrising.org/blog/2025/05/15/t-cell-exhaustion-chronic-fatigue-long-covid/

#COVID #COVID19 #MECFS #LongCOVID #CovidIsNotOver #TCells #NKCells #CD8 #CD4

Oh look, scientists claim they can sneak #mRNA into T cells to tackle #HIV latency—because if there's anything more efficient than human cells, it's #tech that suggests you upgrade your browser. 🙄🖥️ Maybe next they'll solve world hunger with a new app that only works on Netscape. 🍽️✨
https://www.nature.com/articles/s41467-025-60001-2 #Tcells #latency #science #innovation #humor #HackerNews #ngated

Efficient mRNA delivery to resting T cells to reverse HIV latency

https://www.nature.com/articles/s41467-025-60001-2

#HackerNews #Efficient #mRNA #delivery #to #resting #T #cells #to #reverse #HIV #latency

mRNAdelivery #HIVresearch #Tcells #HIVlatency #medicalinnovation #biotechnology

What if your immune system had a second, secret step that made it smarter and stronger? It does—and scientists just found it. #ImmuneBreakthrough #VaccineInnovation #Tcells

https://geekoo.news/the-immune-systems-hidden-power-move-a-second-phase-of-t-cell-activation/

Regulatory #Tcells (Tregs) exist in distinct subsets, but how is this regulated? Saxena & He explore a recent @PLOSBiology study showing that the class III PI3K Vps34 acts as a master orchestrator, driving effector #Treg generation & maintenance. Paper: https://plos.io/42xmddU Primer: https://plos.io/4lz0hYA

Even mild infections trigger the body's defense mechanisms for severe diseases. Discover how our immune system stays one step ahead. #ImmuneResponse #HealthResearch #TCells

https://geekoo.news/early-immune-response-how-t-cells-prepare-for-potential-severe-infections/

Dietmar Zehn, Professor of Animal Physiology and #Immunology, and his team showed that the body prepares itself for a severe course of illness even in the case of uncomplicated #infections by producing special #Tcells: http://go.tum.de/664167

@HelmholtzMunich

📷A.Eckert

Immunotherapy of Camcer #ITOC11 conference started with a packed program and auditorium. Plenty of topics from immunobiology to clinical experimental immunotherapies. See www.itoc-conferences.eu
#immunotherapy #science #Immunology #medicine #TCells #tcellreceptors #cellulartherapies #macrophages #health

THE EXPERT EDGE BY ZPONZ:Expert in T Cells
Dr. Elias Sayour is the principal investigator of the RNA Engineering Laboratory within the Preston A. Wells, Jr. Center for Brain Tumor Therapy and UF Brain Tumor Immunotherapy Program. He is working to develop lipid-nanoparticles to train the immune system to fight cancer. Dr. Sayour's specialty is pediatric hematology-oncology.
#ZPONZ #GetPaidForExpertise #MonetizeYourSkills #ZPONZApp #Tcells

🎉 Groundbreaking news: #aspirin, the hero of headaches, moonlights as a cancer-fighting ninja! 🥋Scientists discover it foils platelet TXA2's evil plot against T cells, while Nature.com battles browser compatibility issues like it's 2005. 🖥️
https://www.nature.com/articles/s41586-025-08626-7 #cancerresearch #Tcells #Naturecom #healthnews #scienceupdates #HackerNews #ngated

Ultrasonic vibrations, transmitted to killer T cells via micro bubbles, trigger a 3.6 fold greater release of tumor killing proteins from the T cells. #ultrasound #cancer #microbuttles #tcells #cytokines
https://www.instagram.com/p/DF_E2emOYkR/

Energize Cancer Killing T cells By Neutralizing Tumor Waste: An alternative immunotherapy strategy. #tcells #killercells #lacticacid #mct11 #transporter #cancer
https://www.instagram.com/p/DChra0zuq0F/

Another great pre-print from the Killian Schober lab and accompanying tweetorial:
https://www.biorxiv.org/content/10.1101/2024.10.30.620795v1
https://x.com/kischober/status/1852222988822712712
It always feels like Xmas day when I see one of their publications. In this one, they followed the clonotypic and phenotypic dynamics of antigen-specific #Tcells from #SARS-CoV2 vaccinated individuals and found that peripheral clonotype expansion was more probabilistic than avidity driven. #immunology

Understanding Long COVID
Through CD8+ T Cell Responses

SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over two years
https://www.pnas.org/doi/10.1073/pnas.2411428121

See Also: Mast Cell Activation Episode
https://www.buzzsprout.com/2405788/episodes/15875307

#CD8 #TCells #LongCovid #Vaccines #Study #TwoYears #Immunity ##Durability

https://www.buzzsprout.com/2405788/episodes/15952636

today I watched:

How Alzheimer's mutates the immune system | nature video

https://youtu.be/o_dbdhwNbig?si=P53kD4ckA45YXKRL

5 min. interview with David Gate on CXCR3 expressing peripheral T cells and Alzheimer disease.

~

I wonder if thiamine deficiency increases CXCR3 expression?

#2dayIwatched #Alzheimers
#NeurodegenerativeDiseases
#Tcells #BrainHealth #immunology #neuroscience

Surprise Discovery: Scientists Discover New Anti-Cancer Potential of Salt
https://scitechdaily.com/surprise-discovery-scientists-discover-new-anti-cancer-potential-of-salt/ #salt #cancer #Tcells #Immunology

Know your neighbours…🏘️

Spatial positioning determines tissue-resident memory T cell fate in the gut.

Marina Schernthanner covers work from Miguel Reina-Campos & colleagues. #preprint

#preLight ⬇️ 👀

https://prelights.biologists.com/highlights/functional-diversity-of-memory-cd8-t-cells-is-spatiotemporally-imprinted-v2/

#biology #immunology #intestine #TCells #bioinformatics #transcriptomics

Quality & longevity of CD4+ #Tcells change with age in mice. @AYatesGroup &co show that these cells have longer lifespans and become more quiescent when the organism ages, but these properties depend on cellular age, not on host age #PLOSBiology https://plos.io/46PBjgX

"Viral persistence and sustained immune activation are linked to Long Covid."

https://www.science.org/doi/10.1126/scitranslmed.adk3295

#LongCOVID #NotInYourHead #SARSCov2 #Virology #ChronicDisease #ViralInfection #ViralRNA #ImmuneCells #TCells #ViralPersistence