“Substance use disorders (SUDs) lead to the early onset of age-related diseases and pose a critical global health challenge, ranking as the fifth cause of years lived with disability, the ninth cause of disability-adjusted life years, and the 15th cause of years of life lost due to premature mortality.” #dna #isogg #epigenetics #mitochondial
https://genomicpress.kglmeridian.com/view/journals/genpsych/aop/article-10.61373-gp025a.0029/article-10.61373-gp025a.0029.xml
ISOGG
Founded in 2005, the mission of the International Society of Genetic Genealogy is to: Advocate for and educate about the use of genetics as a tool for genealogical research while promoting a supportive network for genetic genealogists.
How do we accomplish our mission? By educating others about the use of genetics in genealogy. This is done through workshops, our wiki, a speaker's bureau, our forums, and meetings. ISOGG is FREE! To join: isogg.org #ISOGG #DNA #epigenetics #Fedi22
“Researchers designed CRISPR-based tools to edit neuron epigenomes, focusing on DNA methylation. This breakthrough could advance personalized treatments for neurological disorders by accounting for both genetic and environmental factors.” #isogg #epigenetics #DNA #geneadons
https://www.asbmb.org/asbmb-today/science/042525/crispr-epigenome-editor-treat-neuro-disorders
“A stool sample, he explains, would contain DNA from colon tissue to help medical providers see evidence of mutations—the more mutations, the higher someone’s risk of colorectal cancer. Once you know someone is at high risk, you can take greater steps to monitor and catch the cancer early.” #dna #epigenetics #isogg #coloncancer #ecoli #colorectalcancer
https://news.yahoo.com/childhood-exposure-bacteria-could-driving-153230012.html
“So what has to happen is that methyltransferase has to hit that site over and over and over again, and it gradually builds up methylation … and only with repeated hits from the methyltransferase do we build up enough methylation that the gene actually gets silenced.” #DNA #isogg #Epigenetics #methylation #geneadons
https://www.chemistryworld.com/news/epigenetic-editors-enter-clinical-trials/4021267.article
“Instead, the genetics indicate the emergence of more expansive forms of relatedness, spanning ever-greater parts of the island during the fourth millennium BC, that were enabled and reflected by the construction, use and modification of these monuments.” #DNA #isogg #ancientdna #Ireland #Irish
“In the study, published March 14 in Science, the researchers found that linoleic acid can activate a major growth pathway in tumor cells by binding to a protein called FABP5.” #DNA #epigenetics #isogg #linoleicacid #geneadons
“Now, researchers from UC San Diego and their colleagues have found that HPV DNA hybridizes with human DNA genes in oropharyngeal cancer cells, forming extrachromosomal circular DNA (ecDNA) that promotes tumor growth.” #dna #isogg #epigenetics #mutations #geneadons #cancer #HPV
“At first, researchers were only able to recover the women’s mitochondrial DNA, which gets passed down from mothers. But, eventually, they were able to sequence the mummies’ full genomes, which gave them a more complete understanding of their ancestry.” #DNA #ISOGG #ancientdna #Smithsonian #geneadons
“The main takeaway from the study is that the mind may be resilient and be able to put things behind it, but the body doesn’t forget. It may remain on alert, waiting for the next thing to happen,” said Phebe Tucker, M.D. author of the study.” #isogg #epigenetics #DNA #geneadons
https://neurosciencenews.com/body-trauma-inflammation-28620/
When someone has a mutated version of both copies of their MAL genes, they end up with an AnWj-negative blood type, like the pregnant patient. Tilley and team identified three patients with the rare blood type that didn't have this mutation, suggesting that sometimes blood disorders can also cause the antigen to be suppressed. #bloodgroup #MAL #epigenetics #isogg #geneadons https://www.sciencealert.com/researchers-identify-new-blood-group-after-50-year-mystery#
“The primary goal was to investigate the genotoxicity of 32 commonly consumed food additives and six mixtures corresponding to dietary exposure in France. While our findings indicate the potential toxicity of some combinations, further research is needed to determine whether the in vitro concentrations used are predictive of a possible human health risks.” #DNA #ISOGG #epigenetics #foodadditives #geneadons
https://www.sciencedirect.com/science/article/pii/S0278691524007646?via%3Dihub
“CeCe Moore uncovered genetic evidence that Jane Gates’ youngest child was fathered by Charles Wesley Kelley, a farmer. Kelley was killed at 35 years old by lightning while closing a window, according to a local paper.” #isogg #DNA #geneticgenealogy #geneadons #PBS #findingyourroots
https://www.today.com/today/amp/rcna200312
“Dr. Harrison said, shingles vaccines appear to have “some of the strongest potential protective effects against dementia that we know of that are potentially usable in practice.” #isogg #epigenetics #DNA #dementia #shingles #vaccine #geneadons
https://www.nytimes.com/2025/04/02/health/shingles-vaccine-dementia.html
CeCe Moore gave a preview of this episode at #RootsTech - be sure to tune in on Tuesday. #FindingYourRoots #DNA #geneticgenealogy #isogg #DrHenryLouisGates #CeCeMoore #geneadons https://www.pbs.org/show/finding-your-roots/
“Our data suggests that improving beta-oxidation efficiency can decelerate bioenergetic aging and disease progression. The estimated treatment effects of targeting.” #DNA #Epigenetics #isogg #Alzheimers #geneadons
“The researchers found the changes in gut bacteria communities were associated with a decrease in riboflavin and biotin in people with Parkinson's disease.” #dna #epigenetics #parkinsons #gutbiome #geneadons
https://www.sciencealert.com/parkinsons-gut-bacteria-link-suggests-an-unexpected-simple-treatment#
“Some southern San in South Africa still preserve this ancient, Pleistocene-derived genetic signature, extending the period of genetic continuity until today.” #DNA #ISOGG #genetics #ancientdna #geneadons
“Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour.” #DNA #ISOGG #Epigenetics #microbiome #geneadons
“Nevertheless, taken altogether, the presence of long IBD sharing between the Hun and late Xiongnu groups and the genetic split time estimates, suggest that the ancestors of the Hun group are at most a few hundred years away from the late Xiongnu group.” #DNA #ISOGG #ancientdna #Huns #Xiongnu #Geneadons
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