How the immune system self-instructs to produce #antibodies with increasing affinity to antigens. #affinitymaturation #Bcells https://www.science.org/doi/abs/10.1126/science.adr6896?af=R

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

https://insight.jci.org/articles/view/179433

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

#scRNAseq #TCR #carTcells #OpenAccess #science

Plenary Speaker Profile: Meet Dr. Oliver Harrison, Assistant Member at the Benaroya Research Institute and Affiliate Assistant Professor at the University of Washington who will speak about antigen-level resolution of commensal-specific B cell responses at #HavingIMPACTT2024

#microbiome #microbiota #immunology #bcells #antigen #conference #symposium

Researchers discovered that #Bcells play an active role in teaching #Tcells not to attack the body itself. If the "training" fails, #autoimmunediseases such as #neuromyelitis optica can develop: http://go.tum.de/562972

#thymus #Neuroimmunology

📷J. Böttcher, T. Korn

The great thing about high profile moron “experts” making blithe uninformed comments such as “Covid doesn’t really damage the immune system” is it angers people who ACTUALLY know & they come at them with #CovidPapers #Jha

This will be my continuing🧵on anything related to the destruction of #tcells #bcells #ImmuneDysregulation in an attempt to be organized if only for myself🖤

Published January 14, 2022
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-02228-6

In truth just skimmed but my grasp on this in January 2024 is something that would have been impossible for me to understand in 2022 while experiencing my #sarscov2 2nd infection b/c my level of biology was zero & my lack of understanding led me to believe #hybridImmunity would give me 2 years at least. Mind you I never took my mask off except w/my MIL🦃🎄2021

Philip Dettmer “immune” book along w/the incredibly intelligent🧠🧠🧠here🐘&🐦have been invaluable in at least allowing me to read & generally follow along

Basically this study tells me, stay down for 6 months minimum

On a totally unrelated note🙄
https://www.youtube.com/watch?v=BlQOgs9fzc4

I know :deadbirb: :twitterfire: is bad, but I do love
sue @🖤 inkblue01 who has the best info
#tcells #bcells #cancer

@EeyoreTheCat @BlackAzizAnansi
HA!
HAAAAAAAAAAAAA!

This 2024 variant is equally as bad as 2022 & 2020 I can confidently report from the trenches☹️

Just b/c people have a broken #immuneSystem #ImmuneDysregulation #tCells #bCells from #constantCovid & aren’t displaying reactive symptoms indicative of a healthy immune system, the non-response “just a cold” isn’t the flex they think it is

https://www.science.org/doi/10.1126/sciadv.adg5461

@thepoliticalcat
#eatOutToHelpOut
Psychopaths are in power
The way I personally differentiate between garden variety sociopaths & psychopaths is the willingness to kill w/disregard

They fear what happened to the economy in 2020-2021 will happen again

Short term gains is all anyone cares about

Psychopaths are really insecure yet they possess an amount of #hubris that’s other worldly & believe they are special & will somehow be unscathed. I was “blessed”(🙄) w/an insane family to observe, not formally educated in it

This article is obvi meant to placate fears of getting repeatedly sick & preys on people’s ignorance of immune system

I fell for vague articles like this early on talking abstractedly about #Bcells #Tcells etc

These charlatans are #gaslighting people to their deaths. The🚑🚒🚨🚨🚨#nyc have been constant again & expect it will maintain this level until spring

Great thread!
#Bcells #plasmacells

@Plasmacellguy https://fediscience.org/@Plasmacellguy/111385717686213576

Seung Kim, Frederick Dick et al show that resting #Bcells are uniquely sensitive to #EZH2 #polycomb complex inhibition, which activates expression of repetitive genomic elements and subsequent #innateimmune receptor signaling in a form of viral mimicry

https://www.embopress.org/doi/full/10.15252/embj.2023114462

Electric Pulses Induce Lung Cancer Immune Response

Results of a clinical trial show a lung cancer therapy using highly focused pulses with electrical energy show signs of immune responses that can treat the patients' tumors.

https://sciencebusiness.technewslit.com/?p=45375

#News #Press #Science #Business #Cancer #LungCancer #Therapy #ElectricField #ClinicalTrial #Resection #Surgery #Ablation #MedicalDevice #ImmuneSystem #BCells #TCells

A blood test for long #Covid is possible, new research suggests
The research is among the first to prove that "#LongCovid is, in fact, a biological illness," said David Putrino, principal investigator of the new study and a professor at the Icahn School of Medicine at Mount Sinai in New York. The activity of #immune system cells called #Tcells and #Bcells — which help fight off #germs — was "irregular" in long Covid patients, Putrino said.
https://www.nbcnews.com/health/health-news/long-covid-differences-blood-test-study-finds-rcna116871

Congrats to Louisa Hill from the lab of Meinrad Busslinger
for receiving the Karl Landsteiner Award of the Austrian Society of Allergology and #Immunology! Her research on DNA looping & recombination in developing #bcells revealed the mechanisms behind #antibody diversity.
👉🏾 https://www.imp.ac.at/news/article/karl-landsteiner-award-for-louisa-hill

Referenced link: https://medicalxpress.com/news/2023-06-macrophages-rapidly-digest-dying-cells.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-macrophages-rapidly-digest-dying-cells.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1668251600500973571#m

RT by @physorg_com: Macrophages that rapidly digest dying #Bcells may point to future autoimmune disorder treatments @JExpMed https://rupress.org/jem/article/220/4/e20222173/213834/Tingible-body-macrophages-arise-from-lymph-node https://medicalxpress.com/news/2023-06-macrophages-rapidly-digest-dying-cells.html

Referenced link: https://medicalxpress.com/news/2023-06-uncovers-cells-react-skin-cancer.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-uncovers-cells-react-skin-cancer.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1666852164860358661#m

RT by @physorg_com: Study uncovers how #Bcells react to skin cancer @kingscollegelon @NatureComms https://www.nature.com/articles/s41467-023-39042-y https://medicalxpress.com/news/2023-06-uncovers-cells-react-skin-cancer.html

📢 New review on the functions of double-negative #Bcells in #AutoimmuneDiseases, #infections, and #cancers

By N-W Kam, W Dai & colleagues at University of Hong Kong

🗞️ Read #openaccess: https://doi.org/10.15252/emmm.202217341

wow. i LOVE this type of science.
the one that re-writes text books.
Seems that igM in the blood stream never comes alone and interacts with CD5L (a protein that is not generated by B cells). Congrats to the teams of Albert Heck and my dear colleagues and their teams from #Sanquin, #Gestur Vidarsson and #Theo Rispens

https://www.biorxiv.org/content/10.1101/2023.05.27.542462v1

#immunology #Bcells #textbook

DartLab was happy to play a small role in this just-published study looking at Omicron breakthrough infections. The take-home message is that infections with Omicron after vaccination broaden the existing antibody repertoire. #COVID19 #Bcells #antibody https://www.nature.com/articles/s41467-023-38345-4

important new work by @KhaderShabaana lab highlighting the impact of #Bcells during #Tuberculosis. best of all - they are crucial players in protection after vaccination/challenge! https://rdcu.be/c83ty