#MASLD

GastroAGIGastroAGI
2026-02-02

🔬 GastroAGI — February 2026 Updates

February updates are live on GastroAGI, covering key areas in gastroenterology and hepatology, including Liver Transplantation, Endoscopy, IBD, GI Oncology, Upper GI disorders, Cirrhosis, and Fatty Liver Disease (MASLD).

Explore more: gastroagi.com

GastroAGIGastroAGI
2026-01-16

đź§Ş Autoantibodies & MASLD Outcomes
ANA (17%) and ASMA (25%) are common in MASLD.
Their presence signals worse prognosis:

⚠️ ~4× higher risk of liver decompensation

⚠️ >2× higher mortality
Autoantibodies act as markers of immune activation and predict
progression to cACLD.

➡️ Useful for risk stratification & closer monitoring.

GastroAGIGastroAGI
2026-01-15

đźš­ Smoking increases MASLD risk

by 30–41% in a dose-dependent manner; ≥20 pack-years raises risk by ~32%. Passive smoke exposure increases risk by 13%. Mechanisms include oxidative stress, insulin resistance, inflammation, and gut–liver axis disruption.

Quitting smoking for >10 years reduces MASLD risk to levels comparable with non-smokers.

2025-11-28

Sorbitol fuels dangerous fatty liver disease in lab study

Key Points

  • Study links sorbitol to fatty liver in lab tests. This happened when gut bacteria were weakened by antibiotics.
  • Sorbitol appears to travel to the liver without breakdown. Healthy gut microbes normally stop that harm from occurring.
  • Scientists warn many sugar-free products contain sorbitol daily. People with weak microbiomes may face higher risk.

Scientists warn a common sweetener may help cause serious liver disease. A new study in Science Signalling links sorbitol to MASLD in lab tests.

Getty Images / Stock Photo

How the gut blocks sorbitol

Researchers studied zebrafish and found harm when gut bacteria were depleted. ValidUpdates recently reported Turkish court rules Instagram likes this week.

The team gave antibiotics to reduce gut bacteria in the fish. After this change, sorbitol reached the liver and caused fat buildup.

Normally gut microbes break down sorbitol before it reaches the liver. Loss of that shield let sorbitol travel and harm liver cells.

The authors warn human gut damage could cause the same effect. They call for more study of sorbitol in real diets soon.

What this means for shoppers

The condition MASLD affects many people and often has no symptoms today. Experts say gut health is a rising focus for liver care too.

Public health groups may now reevaluate sorbitol safety in food. See recent commentary on lifestyle and health at Eedris Abdulkareem urges men to marry.

Researchers call for human studies to confirm the zebrafish findings..Until then, people should consider gut health when choosing sweeteners.

Clinicians may start screening patients for gut microbiome problems more often. Simple diet changes and probiotics might help restore gut bacteria.

Food makers could face pressure to label sorbitol content clearly. Regulators may review safety rules for sugar-free additives and sweeteners.

Researchers urge people to avoid unnecessary antibiotics when possible today. That could help keep the microbiome strong and protective against sorbitol.

The study used zebrafish because their liver biology mirrors ours. But scientists note human trials are needed for firm conclusions.

For now, experts recommend varied diets rich in fibre and fermented foods. These foods help feed beneficial gut bacteria and reduce risk.

Public advice may include checking product labels for sorbitol content today. Consumers can choose alternatives with less sugar alcohols when available or advised.

Health groups will watch for follow-up human studies and guidance. News outlets and regulators will likely report new findings quickly to the public

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#diet #health #liver #masld #microbiome #research #sugarFree #validupdates

A close-up image showing many pieces of pastel-coloured chewing gum, including pink, white, green and light grey pieces, scattered together.

Mitochondria in the heart, skeletal muscle, kidney, and liver of individuals with Type 2 diabetes or with fatty liver disease have a diminished ability to produce energy from ketone bodies.

Summary: medicalxpress.com/news/2025-11

Original paper: thelancet.com/journals/ebiom/a

#Science #Health #Diabetes #MASLD #Ketones

Dining and Cookingdc@vive.im
2025-08-29

Mediterranean Diet and Exercise Improve Outcomes in MASLD, MASH

Lifestyle changes—specifically the Mediterranean diet and aerobic exercise—can meaningfully improve liver health in patients with metabolic dysfunction–associated steatotic liver disease (MASLD) and metabolic dysfunction–associated stea…
#dining #cooking #diet #food #MediterraneanDiet #lifestylefactors #MASLD/MASH #Mediterranean
diningandcooking.com/2256915/m

Mediterranean Dietmediterraneandiet@vive.im
2025-08-29

Mediterranean Diet and Exercise Improve Outcomes in MASLD, MASH

Lifestyle changes—specifically the Mediterranean diet and aerobic exercise—can meaningfully improve liver health in patients with metabolic dysfunction–associated steatotic liver disease (MASLD) and met…
#dining #cooking #diet #food #mediterranean #MediterraneanDiet #MediterraneanFood #lifestylefactors #MASLD/MASH #Mediterranean
diningandcooking.com/2256915/m

Jo at Medical News BulletinMedicalNewsBulletin
2025-07-28

Bulletin: Lancet commmission on liver cancer urges action to address hep A, alcohol abuse and non alcoholic fatty liver disease. As many as 60% of liver cancer cases are preventable. medicalnewsbulletin.com/liver-

A mouse study illustrates the effect of environmental temperature on obesity, diabetes, and liver disease. Lab mice are ordinarily housed at a thermoneutral temperature for humans (22 C) rather than for mice (30 C). Mice fed a western diet were more obese, and had greater activation of genes associated with inflammatory and fibrotic responses in the liver.

cell.com/iscience/fulltext/S25

#Science #LiverDisease #MASLD #Obesity

2025-05-30

2/3 Jede:r vierte Deutsche hat eine #Fettleber oder #MASLD, die Therapiemöglichkeiten sind begrenzt. Koordiniert von der #CharitéBerlin untersuchen Forschende im neuen #SFB/Transregio Mechanismen der Krankheit, um sie besser behandeln oder vermeiden zu können.

@tudresden #MedMastodon #Forschung #Förderung #Leber #Hepatologie #Gastroenterologie

Die stoffwechselbedingte Fettlebererkrankung behandeln und ihr Entstehen vorbeugen, ist das Ziel der Berliner und Dresdener Forschungsgruppen im neuen Verbund SFB/TRR 412 © Charité
Geekoogeekoo
2025-03-26

New study: Fatty liver disease doubles mortality risk, affecting liver health and increasing deaths from heart disease and cancer. Learn more about MASLD's impact.

geekoo.news/fatty-liver-diseas

2024-07-23

Liver Disease, in the form of #MASLD and #MASH, is one of the most serious and common complications of obesity, yet few people recognize the risk.
conscienhealth.org/2024/07/mas

2024-03-21

Two pennies per day to prevent #MASLD from progressing with low-dose #aspirin? This is a new study in @jama_current that has our attention. Preliminary? Definitely. But very interesting.
conscienhealth.org/2024/03/low

Matt Willemsenmattotcha
2024-01-16
2023-12-04

When #stigmatizing labels get in the way of talking about a serious chronic disease, it's time to choose words more carefully. This is why #MASLD has replaced #NAFLD.
conscienhealth.org/2023/12/is-

Antje Hellwichantje@mrtodon.net
2023-11-29

MR Elastography Using the Gravitational Transducer by Professor Ralph Sinkus (King’s College London); Omar Darwish (Siemens Healthineers); et al.

The gravitational transducer concept, combined with advanced and fast #MRI sequences and robust inversion algorithms, enables non-invasive, high-quality, and versatile assessment of biomechanics, leading to better diagnosis and staging of liver fibrosis and inflammation in #MASLD (former NAFLD).
Learn more at marketing.webassets.siemens-he

#magnetomworld

2023-11-14

Single-cell #transcriptomics of human liver #organoids stratify models of #metabolic dysfunction-associated steatosis #MASLD
Anja Hess, Alan Mullen et al
embopress.org/doi/full/10.1525

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