Lmst

Brilliant work by #WhiteheadInstitute researchers and collaborators unpacking MECP2’s complex role in Rett syndrome - as both a gene activator and repressor. A powerful step toward more targeted therapies. #RettSyndrome #Neuroscience #Genetics #MECP2 #ScienceMatters #JaenischLab #YoungLab

RE: https://bsky.app/profile/did:plc:376brirdwae4fayb4sd3bzdy/post/3lp5hlxwl722j

A common #parasite could deliver #drugs to the #brain—how scientists are turning #Toxoplasma gondii from foe into friend.

#MeCP2

https://theconversation.com/a-common-parasite-could-one-day-deliver-drugs-to-the-brain-how-scientists-are-turning-toxoplasma-gondii-from-foe-into-friend-235928

Dear #RettSyndrome community and #MeCP2 aficionados. I will give a talk at the 2023 Rett Syndrome Scientific Mtg in Nashville, TN 👉 June 5-7. Thanks to the IRSF and the meeting's scientific committee for the invitation 🙏 More info to come ;-)

https://www.rettsyndrome.org/2023scientificmtg/

FDA approval of trofinetide may spur further drug development for Rett

https://www.spectrumnews.org/news/fda-approval-of-trofinetide-may-spur-further-drug-development-for-rett/

#Rettsyndrome #mousemodels #treatments #autism #MECP2 #News

Debut drug for Rett syndrome at edge of approval

https://www.spectrumnews.org/news/debut-drug-for-rett-syndrome-at-edge-of-approval/

#fragileXsyndrome #Rettsyndrome #mousemodels #treatments #autism #DSM-IV #MECP2 #News

Going on Trial: Orphan drugs; CBD; bumetanide

https://www.spectrumnews.org/news/going-on-trial-orphan-drugs-cbd-bumetanide/

#inhibitorysignaling #fragileXsyndrome #clinicaltrials #Rettsyndrome #genetherapy #mousemodels #funding #autism #22q11 #MECP2 #News #FMR1

Epigenome edits unmute MECP2 in Rett-like neurons

https://www.spectrumnews.org/news/epigenome-edits-unmute-mecp2-in-rett-like-neurons/

#Rettsyndrome #genetherapy #mousemodels #autism #MECP2 #News

“Of the 8 women that completed psychological evaluation and the Symptom Checklist 90-R, half were treated for depression prior to the birth of a child with MDS. All 8 women exhibited symptoms of anxiety and for six, anxiety was present prior to the birth of the affected child.”

👉 Yes, studying #MeCP2, #Epigenetics, #RettSyndrome, and #MDS is important.

👉 Yes, studying #anxiety, #depression, and #screening for better drugs is essential.

https://ojrd.biomedcentral.com/articles/10.1186/s13023-022-02278-w

RNA rewrite improves breathing, survival in Rett mice

https://www.spectrumnews.org/news/rna-rewrite-improves-breathing-survival-in-rett-mice/

#Rettsyndrome #genetherapy #mousemodels #autism #MECP2 #News