How Neurons, Hormones, and Systems Collaborate to Power Your Feelings and Movements
#Neuroscience #BrainAndBody #ScienceExploration #Neurons #SynapticPlasticity #Hormones # NervousSystem #CellBiology #BrainFunctions #MindAndBody #MedicalScience #LearningAndMemory #Neurotransmitters #BrainHealth #ScienceEducation
The Marvel of Auditory and Cognitive Networks Working Together in Your Brain
#AuditoryProcessing #BrainScience #NeuralNetworks #CognitiveScience #Hearing #SpeechRecognition #BrainPlasticity #CentralNervousSystem #SoundProcessing #Neuroscience #ListeningSkills #BrainHealth #AuditoryDisorders #LearningAndMemory
Decoding the Brain: Neural Patterns Behind Thinking and Feeling
#BrainScience #Neuroscience #MindAndMemory #BrainConnections #MentalHealth #CognitiveScience #NeuralNetworks #BrainFunctions #EmotionalIntelligence #LearningAndMemory #BrainAwareness #NeuroscienceEducation
"Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion" by Toshima et al. (Michael Schleyer) 2025
https://www.biorxiv.org/content/10.1101/2025.01.23.634646v1
Indeed, the field has modernly narrowed the scope of research in associative learning to just the mushroom body.
We'd have to convince Yoshi Aso, Glen Turner and Gerry Rubin, regarding the title edit. Have you written to them about this? Particularly Yoshi.
Excessive olfactory memory in the insomniac fruit fly mutant:
"we report our surprising findings that insomniac (inc) Drosophila short sleep mutants, which lack a crucial adaptor protein for the autism-associated Cullin-3 ubiquitin ligase, exhibited excessive olfactory memory."
And then the paper goes on to inquire into the molecular basis of this, and reports:
"find that a mild attenuation of Protein Kinase A (PKA) signaling specifically rescued the sleep and longevity phenotypes of inc mutants. Surprisingly, this mild PKA signaling reduction further boosted the excessive memory in inc mutants, coupled with further exaggerated mushroom body overgrowth phenotypes."
From:
"Cognitive hyperplasticity drives insomnia", by Huang et al. (Sigrist lab) 2024
https://www.biorxiv.org/content/10.1101/2024.07.16.603670v1.full
Latest from Gaia Tavosanis' lab: "How does the fly mushroom body support odour categorisation and discrimination? 🧠✨ Dive into Ivy Chan's findings on how neural circuits enable complex olfactory processing in flies."
"Odour representations supporting ethology-relevant categorisation and discrimination in the Drosophila mushroom body", Chan et al. 2025 (Tavosanis' lab)
https://www.biorxiv.org/content/10.1101/2025.01.25.634657v1
#Drosopila #neuroscience #LearningAndMemory
"Driver lines for studying associative learning in Drosophila" by Shuai, Sammons et al. 2024 (Yoshi Aso's lab).
https://elifesciences.org/reviewed-preprints/94168
@futurebird One key difference in the moth vs. the fruit fly:
"larvae trained at third instar still showed odor aversion after two molts, as fifth instars, but did not avoid the odor as adults, consistent with the idea that post-metamorphic recall involves regions of the brain that are not produced until later in larval development."
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001736
... whereas fly larvae don't develop further brain regions during larval life.
#moths #LearningAndMemory #neuroscience #development #Drosophila
"Selective consolidation of learning and memory via recall-gated plasticity", Lindsey and Litwin-Kumar, 2024.
https://elifesciences.org/reviewed-preprints/90793
On forming long-term memories:
"The key component of this model is a mechanism by which a long-term learning and memory system prioritizes the storage of synaptic changes that are consistent with prior updates to the short-term system. This mechanism, which we refer to as recall-gated consolidation, has the effect of shielding long-term memory from spurious synaptic changes, enabling it to focus on reliable signals in the environment."
With a discussion including mammalian and insect brains.
#neuroscience #LearningAndMemory #RecallGatedConsolidation #CompNeurosci
"Beyond prediction error: 25 years of modeling the associations formed in the insect mushroom body", a review by Barbara Webb 2024.
"Tyramine and its Amtyr1 receptor modulate attention in honey bees (Apis mellifera)", Latshaw et al. 2013 (Brian Smith's lab).
https://elifesciences.org/articles/83348
Genetics and crosses in honeybees: the patience to do these experiments is admirable. Plus electrophysiology!
#honeybees #neuroscience #LearningAndMemory #LatentInhibition
Prof. Karla Kaun and her lab review "Drosophila Reward Circuits" https://oxfordre.com/neuroscience/display/10.1093/acrefore/9780190264086.001.0001/acrefore-9780190264086-e-495
Reviews both the adult and larval Drosophila brain circuits for feeding, sugar sensing, and associative memory, including the roles of neuromodulators and neuropeptides.
Let’s bring back into the limelight Jurgen Schmidhuber’s ~2009 take on compression as the root of a lot that goes on in learning and its impact/causality on beauty, novelty, boringness/interestingness, and action selection.
“Driven by compression progress: A simple principle explains essential aspects of subjective beauty, novelty, surprise, interestingness, attention, curiosity, creativity, art, science, music, jokes” by Schmidhuber 2008. https://arxiv.org/pdf/0812.4360
@elduvelle @LMPrida @biorxivpreprint @cogneurophys I’m stoked that it worked out so well! The assessment followed closely the methods in Navas-Olive CNN paper https://elifesciences.org/articles/77772 using F1 (balanced accuracy) to reflect both precision and recall (i.e. sensitivity). So both FN and FPs count against the score, equally. The human raters were around .7 and the monkey data started at ~.5 and reached ~.6 (same as mouse levels!) after retraining. A pleasant surprise, given visible differences in the SWR phenotype between rodent and primate clades!
I think Andrea will post more details soon, but meanwhile, some relevant keywords for interested folks (can you think of others we should use?)
#neuroscience #MemoryReplay #learningandmemory #hippocampus #ripples #SWR #replay #cnn #lstm #openscience #hackathon #oscillations
"Flexible specificity of memory in Drosophila depends on a comparison between choices", by Modi et al. 2023 (Glenn Turner's lab) https://elifesciences.org/articles/80923
"A memory too specific will be useless in even a slightly different environment, while an overly general memory may lead to suboptimal choices."
"Rather than forming memories that strike a balance between specificity and generality, Drosophila can flexibly categorize a given stimulus into different groups depending on the options available."
Wow Scott—the abstract alone is like a mini neuroscience conference on learning and memory. Looking forward to reading it slowly.
Meanwhile: could you tell us about the voltage imaging? Any caveats?
#Drosophila #neuroscience #LearningAndMemory #MushroomBody #KenyonCells #engran #MultisensoryIntegration
Upcoming learning & memory conference: the mushroom body meeting 2023 has been announced!
When: 30th May – 1st June
Where: Göttingen, Germany
Register at: https://mushroom-body-meeting.org/registration/
Organized by André Fiala, Ilona Grunwald Kadow and Yoshi Aso.
Speaker list: https://mushroom-body-meeting.org/speakers/
Going to #SfN22 ?

Come in for a chat on all things sex differences in memory, feeding, and anxiety:

📚 Sunday Nov 13 8-9am #157.05
“Hippocampal interleukin-6
affects mnemonic functions
and emotionality in a sex-dependent manner”

🍽️ Monday Nov 14 4-5pm #400.17
“From an empty stomach to anxiolysis: molecular and
behavioral sex differences in
ghrelin axis”

See you soon!

#SfN2022 #Neuroscience2022
#IngestiveBehavior #Neuroscience #LearningAndMemory #PhD
Hi everyone!
I am an Assistant Professor in the Dept. of Biology at #HopeCollege (#PUI). I study #Behavior and #Neuroimmunology in mice and humans. My research uses #drugs of abuse (i.e. #morphine and #alcohol) and #space radiation to probe how peripheral #immune responses impact #cognition . I #teach and #mentor #undergraduates (#STEM) how to think about #science and challenge them to question HOW they know content. Here are some other topics/tags that I am fond of: #drugsofabuse #spaceradiation #learningandmemory #adultneurogenesis #microglia #macrophage #mentalhealth
