Q for my fellow neuroscience peeps. Is there a way to stabilize the expression of cre if its under the control of a promoter that is active only transiently during development?
Is it possible to cross a cre line with a cre-dependent cre-expressing reporter mouse so that cre become permanently expressed in the population of interest, and amenable for e.g. virus injection in the adult?
Are there tried and true solutions?
Cannabis compound rebalances signaling to quell seizures in mice
https://www.spectrumnews.org/news/cannabis-compound-rebalances-signaling-to-quell-seizures-in-mice/
#excitatorysignaling #inhibitorysignaling #signalingimbalance #hippocampus #mousemodels #cannabis #epilepsy #autism #News #GABA
‘Splice-switching’ strategy boosts SYNGAP1 expression
https://www.spectrumnews.org/news/splice-switching-strategy-boosts-syngap1-expression/
#mousemodels #treatments #organoids #stemcells #synapses #autism #News
FDA approval of trofinetide may spur further drug development for Rett
https://www.spectrumnews.org/news/fda-approval-of-trofinetide-may-spur-further-drug-development-for-rett/
#Rettsyndrome #mousemodels #treatments #autism #MECP2 #News
Serotonin initiates earliest social bonds
https://www.spectrumnews.org/news/serotonin-initiates-earliest-social-bonds/
#sensoryperception #neuralcircuits #animalmodels #mousemodels #serotonin #oxytocin #News #rats
Debut drug for Rett syndrome at edge of approval
https://www.spectrumnews.org/news/debut-drug-for-rett-syndrome-at-edge-of-approval/
#fragileXsyndrome #Rettsyndrome #mousemodels #treatments #autism #DSM-IV #MECP2 #News
Going on Trial: Orphan drugs; CBD; bumetanide
https://www.spectrumnews.org/news/going-on-trial-orphan-drugs-cbd-bumetanide/
#inhibitorysignaling #fragileXsyndrome #clinicaltrials #Rettsyndrome #genetherapy #mousemodels #funding #autism #22q11 #MECP2 #News #FMR1
Protein networks identified in autism-linked genetic deletion
https://www.spectrumnews.org/news/protein-networks-identified-in-autism-linked-genetic-deletion/
#mousemodels #15q11-13 #autism #axons #News
The clinical presentation of #FragileXSyndrome ranges from
#autism and intellectual disability to #neurodegeneration.
A new Review from Rob Willemsen & Frank Kooy at #erasmusmcintl discusses #MouseModels that improve our understanding of this disease to help develop targeted #therapies
📰https://journals.biologists.com/dmm/article/16/2/dmm049485/286737/
Epigenome edits unmute MECP2 in Rett-like neurons
https://www.spectrumnews.org/news/epigenome-edits-unmute-mecp2-in-rett-like-neurons/
#Rettsyndrome #genetherapy #mousemodels #autism #MECP2 #News
Adult Angelman mice get some benefit from boosting UBE3A gene expression
https://www.spectrumnews.org/news/adult-angelman-mice-get-some-benefit-from-boosting-ube3a-gene-expression/
#Angelmansyndrome #clinicaltrials #geneexpression #animalmodels #genetherapy #mousemodels #treatments #autism #sleep #UBE3A #News #EEG
CHD8 mutation in 33 mouse strains yields range of traits
https://www.spectrumnews.org/news/chd8-mutation-in-33-mouse-strains-yields-range-of-traits/
#macrocephaly #mousemodels #anxiety #autism #News #CHD8
Missing mechanism helps solve fragile X protein mystery
https://www.spectrumnews.org/news/missing-mechanism-helps-solve-fragile-x-protein-mystery/
#intellectualdisability #repetitivebehaviors #socialdifficulties #fragileXsyndrome #neuralcircuits #connectivity #hippocampus #mousemodels #treatments #synapses #autism #News #FMR1 #FMRP
#Longcovid study identifies 4 main subtypes through data analysis of existing patients with #machinelearning.
Covid #mousemodels are available at the MMRRC: https://www.mmrrc.org/catalog/covid_models.php
Research Source: postly.link/kxT
Beyond the bench: Finding solitude with Jill Silverman
https://www.spectrumnews.org/opinion/q-and-a/beyond-the-bench-finding-solitude-with-jill-silverman/
#Angelmansyndrome #mousemodels #autism #UBE3A #QA
Asleep in the Mouse House with Graham Diering
https://www.spectrumnews.org/news/profiles/asleep-in-the-mouse-house-with-graham-diering/
#Phelan-McDermidsyndrome #Rettsyndrome #mousemodels #Profiles #synapses #autism #SHANK3 #sleep
Calming neurons to quell seizures: Q&A with Gabriele Lignani and Dimitri Kullmann
https://www.spectrumnews.org/opinion/q-and-a/calming-neurons-to-quell-seizures-qa-with-gabriele-lignani-and-dimitri-kullmann/
#excitatorysignaling #genetherapy #mousemodels #organoids #epilepsy #autism #QA
@BenFPiercePhD @joncohen of course an unmodified virus can be cultivated in labs these days , and leak and mutate (f.e. in humanised #mousemodels )
Beyond the bench: Finding balance with Gavin Rumbaugh
https://www.spectrumnews.org/opinion/q-and-a/beyond-the-bench-finding-balance-with-gavin-rumbaugh/
#sensoryperception #neuralcircuits #mousemodels #synapses #autism #QA
