Lmst

Reminder: deadline to apply for the Stem Cell Summer School is 30th May. And it's May already! So you have to apply this month!

A limited number of bursaries are available.

p.s. this year, the summer school coincides with the Spetses Armata Festival, so there will be a big party on the island 🙂

https://www.stemcellsummerschool.org/
#StemCells #DevBio #RegenerativeMedicine

European Summer School on Stem Cell Biology and Regenerative Medicine

12-19 September 2025

Spetses, Greece

From molecular networks to breaking therapies. For early career researchers & research-active clinicians. Faculty Cedric Blanpain DavidKent Alejo Rodriguez-Fraticelle James Briscoe Agnete Kirkeby Austin Smith Anna Couturier Sally Lowell Mekayla Storer Michele De Luca Mattias Lutolf Shahragim Tajbakhsh Allen Eaves Christine Mummery Jim Wells Kim Jensen Emma Rawlins Sara Wickstrom

Online Now! Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00141-9?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #stemcells

Online Now! Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00144-4?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #stemcells

Stem cell therapies revolutionize blood cancer treatment, offering new hope through groundbreaking medical research and personalized interventions targeting leukemia, myeloma, and lymphoma. #StemCells #CancerResearch

Creative Biolabs launches comprehensive iPSC services, transforming stem cell research with advanced reprogramming and differentiation technologies. Empowering researchers in regenerative medicine and disease modeling. #StemCells #MedicalResearch

Stem cell therapy emerges as a powerful tool in blood cancer treatment, offering innovative approaches to regenerate damaged cellular systems and provide new hope for patients #StemCells #CancerResearch

BioRestorative Therapies develops groundbreaking stem cell therapies targeting chronic back pain and metabolic diseases, offering innovative solutions for millions of patients worldwide. Personalized treatments promise new hope in regenerative medicine. #StemCells #Healthcare

Creative Biolabs launches comprehensive iPSC services, enabling researchers to advance stem cell therapy with cutting-edge reprogramming and differentiation technologies. Breakthrough solutions for neurological disease research. #StemCells #MedicalInnovation

#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @PLOSBiology https://plos.io/42XBYfH

Schematic of WRNexo function in Drosophila intestinal stem cells (ISCs). WRNexo upregulation and Hsc70-3/Bip translocation to nuclei occur with injury/aging. WRNexo interaction inhibits Hsc70-3/Bip, increasing ER stress, which promotes ISC proliferation via ROS-JNK signaling.

🧠 Cells very similar to neurons obtained from human dental stem cells

https://medicalxpress.com/news/2025-04-cells-similar-neurons-human-dental.html

#biotech #biology #molbio #brain #stemcells #neuron #medicine

Why do #StemCells have lower levels of facultative #heterochromatin, defined by H3K27me3, compared to differentiated cells? By artificially lengthening G1 phase, @4everbiochemist &co show that G1 length is an essential determinant of H3K27me3 landscape @PLOSBiology https://plos.io/4lKfztO

H3K27me3 domains in HEK293 cells change with accelerated cell cycle timing. Top left: Flow cytometry analysis of DNA content using propidium iodide fluorescence for HEK293 cells that were treated with DMSO for 48 h. Bottom left: As above, but HEK293 cells treated with Chiron-124 for 48 h. Top middle: Immunoblot for H3K27me3 and H3 on acid-extracted histones after 48-h treatment with Chiron-124. Bottom middle: Quantification of the modification levels normalized to DMSO-treatment. p-value calculated using two-tailed, homoscedastic student t test. Right: Heatmap of H3K27me3 enrichment at domains defined in DMSO treated cells for DMSO treatment (left) and Chiron-124 treatment (middle), and the log2 ratio of H3K27me3 within domains for Chiron-124 over DMSO (right).

Online Now! Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00102-X?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #stemcells

Online Now! Glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00101-8?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #stemcells

https://www.alojapan.com/1247596/kyoto-hospital-succeeds-in-ips-sheet-transplant-to-diabetic-patient/ Kyoto hospital succeeds in iPS sheet transplant to diabetic patient #diabetes #hospitals #iPS #Kyoto #KyotoTopics #KyotoUniversityHospital #medicine #STEMCELLS #transplants #京都 #京都府 Kyoto – Kyoto University Hospital has succeeded in transplanting pancreatic cell sheets made from induced pluripotent stem (iPS) cells into a diabetic patient, achieving the first clinical application of such sheets in Japan. Announcing the results Monday, the hos…