Nghiên cứu mới về liệu pháp CAR-NK tế bào đồng loại chống ung thư. Các nhà khoa học đã thiết kế tế bào CAR-NK để giảm kháng nguyên HLA và tăng biểu hiện PD-L1, giúp tế bào không bị hệ miễn dịch đào thải. Điều này giúp tăng hiệu quả tiêu diệt khối u, an toàn hơn và mở ra khả năng cho các liệu pháp tế bào "có sẵn".
#CARNK #CancerTreatment #Immunotherapy #OffTheShelf #HLA #PDL1 #YHọc #UngThư #LiệuPhápMiễnDịch #TếBàoGốc #NghiênCứuKhoaHọc
https://www.reddit.com/r/singularity/comments/1o3yb4f/selecti
The November Issue of @CellChemBiol is Online! Read it at: https://www.cell.com/cell-chemical-biology/current?utm_source=dlvr.it&utm_medium=mastodon #chemicalbiology #GPCR #RAF #STING #SARSCOV2 #ASO #PDL1 #HDAC #indoxylsulfate #E3ligase #UPS10 #targetID #luciferin #forwardgenetics
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* regulator protein CMTM6 inhibits degradation of both CD58 (stimulates T cell activity) & cell surface protein PD-L1 (inhibits T cell activity)
* CD58 & PD-L1 compete for binding to regulator protein CMTM6
* tumor cell that express less CD58 free up more CMTM6 to stabilize PD-L1
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity
https://www.sciencedirect.com/science/article/abs/pii/S1535610823001812
https://www.biorxiv.org/content/10.1101/2022.03.21.485049v1
* cancer immune evasion
...
Cancer Cloaking Device Revealed
https://www.cancer.columbia.edu/news/cancers-cloaking-device-revealed
Discussion: https://news.ycombinator.com/item?id=37042790
* Malignant melanoma (skin cancer) deploys elegant molecular mechanism to evade natural immune responses, therapies
* immune system eliminates abnormal cells; cancers can elude it
* tumor cells that suppressed cell surface protein CD58 expression better at escaping immune surveillance
* hinted at how melanomas might be hiding f. T cells
...
#cytokines as #biomarkers for therapeutic success in #NSCLC #nsclctrial #Immunotherapy #pd1 #pdl1 utilizing #MachineLearming , link to downloadable PDF https://bit.ly/3NTxfTt
Incredibly moving to see the positive results for IMbrave050, Tecentriq+Avastin in early stage HCC. Continues to highlight the relationship between #VEGF and #PDL1 #cancer #immunotherapy #HCC @genentech @Roche https://www.gene.com/media/press-releases/14981/2023-01-18/genentechs-tecentriq-plus-avastin-is-the
Beginning now. Looking forward to giving a talk of #Organoids and #PDL1 works @hkumed@twitter.com
This is an excellent landscape map for #cell #therapy #immunotherapy #CART #TCR #cancer. Created by Wells Fargo IG and Posted recently to LI by Basem Goueli. As noted by Jun Tang, The graphic concept originated from Vanessa Lucey from CRI and @IraMellman and I published on it for #PDL1 #PD1 in Nature in 2018 as part of the Immune set point manuscript. Incredible how the field has developed over the last several years.
DGN 2022: Checkpoint-Inhibition - auch neurologisch relevant
https://www.gelbe-liste.de/neurologie/checkpoint-inhibition-neurologisch-relevant
