Within tumors in the human body, there are #immune #cells ( #macrophages ) capable of fighting cancer,
but they have been unable to perform their roles properly due to suppression by the tumor.
KAIST researchers have overcome this limitation by developing a new therapeutic approach that directly ⚠️converts immune cells inside tumors into anticancer cell therapies.
KAIST President Kwang Hyung Lee announced on the 30th that a research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering has developed a therapy in which,
when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR
(a #cancer-#recognizing device) proteins on their own...
and are converted into anticancer immune cells known as "#CAR-#macrophages."
❌Solid tumors—such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function.
As a result, the effectiveness of existing immune cell therapies has been limited.
✅ CAR-macrophages,
which have recently attracted attention as a next-generation immunotherapy,
have the advantage of directly engulfing cancer cells while simultaneously activating surrounding immune cells to amplify anticancer responses.
⛔️However, conventional CAR-macrophage therapies require immune cells to be extracted from a patient's blood, followed by cell culture and genetic modification.
This process is time-consuming, costly, and has limited feasibility for
real-world patient applications.
To address this challenge, the research team focused on "#tumor-#associated #macrophages" that are already accumulated around tumors.
⭐️They developed a strategy to directly reprogram immune cells in the body by loading lipid nanoparticles
—designed to be readily absorbed by macrophages
—with both mRNA encoding
cancer-recognition information
and an immunostimulant that activates immune responses.
In other words, in this study,
CAR-macrophages were created by
👉"directly converting the body's own macrophages into anticancer cell therapies inside the body."
https://www.news-medical.net/news/20260102/New-therapeutic-approach-converts-immune-cells-inside-tumors-into-anticancer-cell-therapies.aspx