A short commentary by the great Anna Gillespie on awake replay:

Ruminating on replay during the awake state

#GillespieLab (https://www.gillespie-lab.com/)

Interesting bits:

"replay during sleep is generally thought to occur in the forward direction"

I believe this is true too, but has anyone actually analyzed it? It could be done on several existing datasets...

"The idea that awake replay might serve a planning role was broadly adopted by the field, even though direct experimental evidence [...] has been slow to emerge"

YES because replay is not related to immediate planning, however nice it would be if it was

"We, as a field, also need to be more precise with our terminology. For instance, what exactly should we consider evidence of ‘planning’ or ‘deliberation’ in an animal model? "

YES

Related: history of the 'genesis' of #ThetaSequences narrated in this retrospective by @adredish: Mental Time Travel: A Retrospective
(original post:
https://neuromatch.social/@adredish/113662497894186335) #RedishLab

I'd actually argue that replay, and not theta sequences, might be closer to mental time-travel... but we probably don't know enough about either to be sure yet!

#Neuroscience #HippocampalReplay #Hippocampus

#VTE detection: what's the best algorithm out there to detect Rat VTEs from 2D head position data (no HD data)?
By "best" I mean least effortful for the user...

I know that @adredish has the D-phil method (explained in Interactions between deliberation and delay-discounting in rats #RedishLab which is used quite a lot.

But also just found out about a different method from @jessetm explained in A Machine Learning Approach for Detecting Vicarious Trial and Error Behaviors #MizumoriLab - Jesse, I haven't checked the details yet but as its creator, would you recommend it? Would you have code for it somewhere? I couldn't see a repo link in the paper but maybe I missed it. 🙏

Edit: Jeff Stott added this one to the list, which uses a "Curvature" measure (also from #RedishLab): A functional difference in information processing between orbitofrontal cortex and ventral striatum during decision-making behaviour

Any other ones out there?
#Neuroscience #NeuroMethods #SpatialCognition

@Andrewpapale for sure, the #RedishLab has pioneered a lot of discoveries. Replications / extensions of results are good though! I want to read these in details and then we could maybe ask the first author John to present at a special #JournalClub!!