#ReversalLearning

Fabrizio Musacchiopixeltracker@sigmoid.social
2025-06-30

Recently, we discussed this insightful paper by Squadrani et al (2024) in our #JournalClub. It explores how #astrocytes enhance #SynapticPlasticity during #ReversalLearning by modulating D-serine levels, providing a #biophysical basis for dynamic #LTP thresholds. The findings suggest astrocytic signaling is crucial for #AdaptiveLearning, linking #glial activity to #behavioral flexibility. Here’s a summary from our JC:

🌍 fabriziomusacchio.com/blog/202
πŸ“ doi.org/10.1038/s42003-024-065

#CompNeuro #Neuroscience

Fig. 4 from Squadrani et al. (2024)κœ›: The model reproduces learning deficit in mutant mice. Top: State visit frequency over time. Bottom: Corresponding synaptic weight evolution for control and mutant simulations. Source: Communications Biology (Commun Biol)κœ› (license: Creative Commons Attribution 4.0 International License)

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